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Oxidation of synephrine by type A and type B monoamine oxidase

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Summary

Synephrine (SP) was found to be a substrate for monoamine oxidase (MAO) in rat brain mitochondria, showing the Km and Vmax values of 250 μM and 32.6 nmoles/mg of protein/30 min respectively. The inhibition studies showed that the SP oxidation was carried out by both type A and type B MAO and a major part of the activity was due to type A MAO.

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Author notes

  1. O. Suzuki

    Present address: Department of Legal Medicine, Hamamatsu University School of Medicine, 3600 Handa-cho, 431-31, Hamamatsu, Japan

Authors and Affiliations

  1. Division of Neurotoxicology, Department of Legal Medicine and Division of Oncology, 1st Department of Surgery, Nagoya University School of Medicine, 466, Nagoya, Japan

    O. Suzuki, T. Matsumoto, M. Oya & Y. Katsumata

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  1. O. Suzuki
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  2. T. Matsumoto
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  3. M. Oya
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  4. Y. Katsumata
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Suzuki, O., Matsumoto, T., Oya, M. et al. Oxidation of synephrine by type A and type B monoamine oxidase. Experientia 35, 1283–1284 (1979). https://doi.org/10.1007/BF01963957

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