Skip to main content
SpringerLink
Log in

Safety and efficacy of lomefloxacin versus norfloxacin in the treatment of complicated urinary tract infections

  • Notes
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

Seventy patients with complicated urinary tract infections were treated with either lomefloxacin (400 mg once daily) or norfloxacin (400 mg twice daily) for 10 to 14 days. A total of 19 (86 %) of 22 patients treated with lomefloxacin and 20 (74 %) of 27 patients treated with norfloxacin were cured, as defined by a negative culture five to nine days after completion of therapy (p=0.09). After four to six weeks, the figures were 56 % for lomefloxacin and 48 % for norfloxacin. Adverse effects in the lomefloxacin group were observed on 20 occasions in 12 patients (one stopped treatment) compared to nine occasions in five patients treated with norfloxacin (difference not significant).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chin NX, Novelli A, Neu HC In vitro activity of lomefloxacin (SC-47111; NY-198), a difluoroquinolone 3-carboxylic acid, compared with those of other quinolones. Antimicrobial Agents and Chemotherapy 1988, 32: 656–662.

    Google Scholar 

  2. Leroy A, Fillastre JP, Humbert G Lomefloxacin pharmacokinetics in subjects with normal and impaired renal function. Antimicrobial Agents and Chemotherapy 1990, 34: 17–20.

    Google Scholar 

  3. Blum RA, Schultz RW, Schentag JJ Pharmacokinetics of lomefloxacin in renally compromised patients. Antimicrobial Agents and Chemotherapy 1990, 34: 2364–2368.

    Google Scholar 

  4. Wolfson JS, Hooper DC Norfloxacin: a new targeted fluoroquinolones antimicrobial agent. Annals of Internal Medicine 1988, 108: 238–251.

    Google Scholar 

  5. Sandberg T, Englund G, Nilsson LG Randomized double-blind study of norfloxacin and cefadroxil in the treatment of acute pyelonephritis. European Journal of Clinical Microbiology & Infectious Diseases 1990, 9: 317–323.

    Google Scholar 

  6. Cherubin C, Stilwell S Norfloxacin versus parenteral therapy in the treatment of complicated urinary tract infections and resistant organisms. Scandinavian Journal of Infectious Diseases 1986, 48, Supplement: 32–37.

    Google Scholar 

  7. Sabbay J, Hoagland VL, Cook T Norfloxacin versus co-trimoxazole in the treatment of recurring urinary tract infections in men. Scandinavian Journal of Infectious Diseases 1986, 48, Supplement: 48–53.

    Google Scholar 

  8. Wadsworth AN, Goa KL Lomefloxacin, a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 1991, 42: 1018–1060.

    Google Scholar 

  9. Hoepelman AI, Bakker LJ, Verhoef J Carumonam (Ro 17-2301; AMA-1080) compared with gentamicin for treatment of complicated urinary tract infections. Antimicrobial Agents and Chemotherapy 1988, 32: 473–476.

    Google Scholar 

  10. Mallinverni R, Glauser MP Comparative studies of fluoroquinolones in the treatment of urinary tract infections. Reviews of Infectious Diseases 1988, 10, Supplement 1: 153–163.

    Google Scholar 

  11. Wolfhagen MJ, Hoepelman AI, Verhoef J Double-blind, dose-range-finding study of fleroxacin (RO 23-6240; AM-833) for treatment of complicated urinary tract infections. Antimicrobial Agents and Chemotherapy 1990, 34: 409–412.

    Google Scholar 

  12. Bowie WR, Willetts V, Jewesson PJ Adverse reactions in a dose-ranging study with a new long-acting fluoroquinolone, fleroxacin. Antimicrobial Agents and Chemotherapy 1989, 33: 1778–1782.

    Google Scholar 

  13. Rademaker CM, Hoepelman AIM, Wolfhagen MJ, Beumer H, Rozenberg-Arska M, Verhoef J Results of a double-blind placebo-controlled study using ciprofloxacin for prevention of travelers' diarrhea. European Journal of Clinical Microbiology & Infectious Diseases 1989, 8: 690–694.

    Google Scholar 

  14. Rademaker CM, Sips AP, Beumer HM, Hoepelman AIM, Overbeek BP, Möllers MJ, Rozenberg-Arska M, Verhoef J A double-blind comparison of low-dose ofloxacin and amoxycillin/clavulanic acid in acute exacerbations of chronic bronchitis. Journal of Antimicrobial and Chemotherapy 1990, 26, Supplement D: 75–81.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, University Hospital, PO Box 85500, 3508 GA, Utrecht, The Netherlands

    I. M. Hoepelman

  2. Eykman-Winkler Institute, University Hospital, PO Box 85500, 3508 GA, Utrecht, The Netherlands

    I. M. Hoepelman & M. A. M. de Wit

  3. Department of Urology, University Hospital, PO Box 85500, 3508 GA, Utrecht, The Netherlands

    I. M. Hoepelman, R. A. Benne, M. R. Visser & J. Verhoef

  4. Rehabilitation Centre ‘De Hoogstraat’, Utrecht, The Netherlands

    H. A. P. M. de Hond & T. A. Boon

  5. U-Gene Research, Utrecht, The Netherlands

    W. H. Havinga & F. W. A. van Asbeck

Authors
  1. I. M. Hoepelman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. H. Havinga
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. A. Benne
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Zwinkels
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. A. M. de Wit
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. A. P. M. de Hond
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. T. A. Boon
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M. R. Visser
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. F. W. A. van Asbeck
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. J. Verhoef
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hoepelman, I.M., Havinga, W.H., Benne, R.A. et al. Safety and efficacy of lomefloxacin versus norfloxacin in the treatment of complicated urinary tract infections. Eur. J. Clin. Microbiol. Infect. Dis. 12, 343–347 (1993). https://doi.org/10.1007/BF01964430

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01964430

Keywords

Search

Navigation