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Influence of decontamination of the digestive tract on the urinary excretion of histamine and some of its metabolites

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Abstract

Urinary excretions of histamine, Nt-methylhistamine and Nt-methylimidazoleacetic acid have been determined for 8 healthy volunteers during 14 consecutive days. Selective decontamination of the digestive tract was performed from day 3 to day 6, followed by total decontamination from day 7 to day 10. Urinary excretions of Nt-methylhistamine and Nt-methylimidazoleacetic acid decreased to a small though significant degree (about 15–20%) after total decontamination, suggesting a histamine production by anaerobic bacteria. Cadaverine decreased for about 70% under both selective and total decontamination, suggesting that this amine in human urine mainly originates from aerobic bacteria in the intestinal tract.

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Authors and Affiliations

  1. Central Laboratory for Clinical Chemistry, University Hospital, Oostersingel 59, POB 30.001, 9700 RB, Groningen, The Netherlands

    J. J. Keyzer, G. A. van den Berg & B. G. Wolthers

  2. Department of Clinical Bacteriology, University Hospital, Groningen

    H. K. F. van Saene

Authors
  1. J. J. Keyzer
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  2. H. K. F. van Saene
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  3. G. A. van den Berg
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  4. B. G. Wolthers
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Keyzer, J.J., van Saene, H.K.F., van den Berg, G.A. et al. Influence of decontamination of the digestive tract on the urinary excretion of histamine and some of its metabolites. Agents and Actions 15, 238–241 (1984). https://doi.org/10.1007/BF01972355

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  • DOI: https://doi.org/10.1007/BF01972355

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