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Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding

  • Pharmacology
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Abstract

We report a 3-week-old boy with cholestatic hepatitis, most likely due to carbamazepine exposure during pregnancy and breastfeeding. Cholestasis resolved after cessation of nursing. Liver function test results and histological findings were compatible with a drug-induced hepatitis. Other causes were excluded. While carbamazepine-induced hepatitis is well known in children and adults, it has never been described in association with prenatal exposure and/or breast-feeding.

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Authors and Affiliations

  1. Children's Hospital, CH-6000, Lucerne 16, Switzerland

    B. Frey & G. Schubiger

  2. Institute of Pathology, CH-6000, Lucerne 16, Switzerland

    J. P. Musy

Authors
  1. B. Frey
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  2. G. Schubiger
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  3. J. P. Musy
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Frey, B., Schubiger, G. & Musy, J.P. Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding. Eur J Pediatr 150, 136–138 (1990). https://doi.org/10.1007/BF02072057

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  • DOI: https://doi.org/10.1007/BF02072057

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