Abstract
Abstract
The Floating-Harbor syndrome is a growth retardation syndrome with delayed bone age, speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. We present an additional patient and review 16 cases from the literature. The possible phenotype in the patient's mother suggests a dominant mode of inheritance for the syndrome.
Conclusion
The Floating Harbor syndrome is a growth deficiency syndrome characterized by proportionate short stature, characteristic face and delayed speech development. Inheritance is possibly autosomal dominant.
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Abbreviations
- FHS :
-
Floating Harbor syndrome
References
Chudley AE, Moroz SP (1991) Floating-Harbor syndrome and celiac disease. Am J Med Genet 38: 562–564
Gorlin RJ, Cohen MM Jr, Levin LS (1990) Unusual facies, short stature, and hypoplastic penis (Floating-Harbor syndrome, Pelletier-Leisti syndrome). In: Motulsky AG, Bobrow M, Harper PS, Seriver C (eds) Syndromes of the head and neck, 3rd edn. Oxford University Press, Oxford, p 914
Houlston RS, Collins AL, Dennis NR, Temple IK (1994) Further observations on the Floating-Harbor syndrome. Clin Dysmorphol 3: 143–149
Leisti J, Hollister DW, Rimoin DL (1974) Case report 2. The Floating-Harbor syndrome. Synd Ident 2: 305
Lipson A (1991) Floating-Harbor and the good ship Shprintzen (Letter). J Med Genet 28: 807–808
Majewski F, Lenard HG (1991) The Floating-Harbor syndrome. Eur J Pediatr 150: 250–252
Patton MA, Hurst J, Donnai D, McKeown CME, Cole T, Goodship J (1991) Syndrome of the month: Floating-Harbor syndrome. J Med Genet 28: 201–204
Pelletier G, Feingold M (1973) Case report. Synd Ident 1: 8–9
Robinson PL, Shohat M, Winter RM, Conte WJ, Gordon-Nesbitt D, Feingold M, Laron Z, Rimoin DL (1988) A unique association of short stature, dysmorphic features, and speech impairment (Floating-Harbor syndrome). J Pediatr 113: 703–706
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Lacombe, D., Patton, M.A., Elleau, C. et al. Floating-Harbor syndrome: description of a further patient, review of the literature, and suggestion of autosomal dominant inheritance. Eur J Pediatr 154, 658–661 (1995). https://doi.org/10.1007/BF02079072
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DOI: https://doi.org/10.1007/BF02079072