Abstract
The effect of meal volume and fat content on gastroesophageal reflux was investigated in 20 asymptomatic healthy subjects. In each subject, intraesophageal pH monitoring was performed during a 3-hr postprandial period (PP) in the same position (supine or upright) on two successive days. On day 1, 500-ml low- and high-fat meals were ingested and, on day 2, an 800-ml low-fat meal was ingested. The acid exposure time was assessed as the percentage of time with a pH<4.0. The acid exposure time in subjects in the upright position was significantly longer in the 800-ml group than in the 500-ml group for the entire PP (2.7 ± 1.5%; mean ±se, 0.7 ± 0.4%;P<0.05). Of subjects in the supine position, the high-fat group showed significantly longer acid exposure time than the low-fat group both for the entire PP (7.6 ± 3.0%, 0.7 ± 0.5%; p<0.05) and for the second hour (P<0.05). We have demonstrated that differences in the meal volume and fat content influence gastroesophageal reflux in healthy asymptomatic subjects and that this influence varies with the position.
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Iwakiri, K., Kobayashi, M., Kotoyori, M. et al. Relationship between postprandial esophageal acid exposure and meal volume and fat content. Digest Dis Sci 41, 926–930 (1996). https://doi.org/10.1007/BF02091532
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DOI: https://doi.org/10.1007/BF02091532