Skip to main content
Log in

Body temperature and acid-base regulation (Review article)

  • Published:
Pneumonologie Aims and scope Submit manuscript

Abstract

Evidence over the last few years would suggest that the observed acid-base equilibrium at various body temperatures is governed by the behavior of the protein buffer, imidazole of peptide histidine. If protein net charge is to remain the same as well as the CO2 stores of blood and tissues as the temperature changes in an open system, it is necessary for the ventilation to adjust itself to the metabolism in such a way that the relative alkalinity of the blood remains constant.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Albery, W. J., Lloyd, B. B.: Variation of chemical potential with temperature. In: Development of the Lung, Edited by A. V. S. de Reuck and R. Porter. pp. 30–33, J. & A. Churchill Ltd., London 1967

    Google Scholar 

  • Albers, C.: Die ventilationische Kontrolle des Säuren-Basengleichgewichts in Hypothermie. Der Anaesthesist11, 43–51 (1962)

    PubMed  Google Scholar 

  • Burton, R. F.: The roles of buffers in body fluids: mathematical analysis. Resp. Physiol.18, 34–42 (1973)

    Article  Google Scholar 

  • Howell, B. J., Baumgardner, F. W., Bondi, K., Rahn, H.: Acid-base balance in cold-blooded vertebrates as a function of body temperature. Amer. J. Physiol.218, 600–606 (1970)

    PubMed  Google Scholar 

  • Jackson, D. C.: The effect of temperature on ventilation in the turtle. Resp. Physiol.12, 131–140 (1971)

    Article  Google Scholar 

  • Kelman, G. R., Nunn, J. F.: Nomograms for correction of blood\(P_{O_2 } \),\(P_{CO_2 } \), pH, and base excess for time and temperature. J. appl. Physiol.21, 1484–1490 (1966)

    PubMed  Google Scholar 

  • Malan, A., Reeves, R. B.: Intracellular pH in turtle(Pseudemys scripta) tissues as a function of body temperature. Physiologist16, 385 (1973)

    Google Scholar 

  • Rahn, H.: Acid-base regulation and temperature in the evolution of vertebrates. Proc. Int. Union Physiol. Sci.8, 91–92 (1971)

    Google Scholar 

  • Rahn, H.:\(P_{CO_2 } \), pH and body temperature. In: Carbon Dioxide and Metabolic Regulations, Edited by G. Nahas and K. E. Schaefer. pp. 152–162. Berlin-Heidelberg-New York: Springer 1974

    Google Scholar 

  • Reeves, R. B.: An imidazole alphastat hypothesis for vertebrate acid-base regulation: Tissue carbon dioxide content and body temperature in bullfrogs. Resp. Physiol.14, 219–236 (1972)

    Article  Google Scholar 

  • Reeves, R. B.: Temperature induced changes in whole blood pH and\(P_{CO_2 } \) at constant carbon dioxide content. Fed. Proc.32, 349 (1973)

    Google Scholar 

  • Robin, E. D., Bromberg, P. A., Cross, C. E.: Some aspects of the evolution of vertebrate acid-base regulation. Yale J. Biol. Med.41, 448–467 (1969)

    PubMed  Google Scholar 

  • Severinghaus, J. W.: Blood gas calculator. J. appl. Physiol.21, 1108–1116 (1966)

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This study was aided by Contract N00014-68-A-0216, (NR101-722), between the Office of Naval Research, Department of the Navy, and the State University of New York at Buffalo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rahn, H. Body temperature and acid-base regulation (Review article). Pneumonologie 151, 87–94 (1974). https://doi.org/10.1007/BF02097155

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02097155

Keywords

Navigation