References
Ninane J A multicentre study of fluconazole versus oral polyenes in the prevention of fungal infection in children with haematological or oncological malignancies. European Journal of Clinical Microbiology & Infectious Diseases 1994, 13: 330–337.
Morita K, Konishi H, Shimakawa H Fluconazole: a potent inhibitor of cytochrome P-450-dependent drug metabolism in mice and humans in vivo: comparative study with ketoconazole. Chemical and Pharmaceutical Bulletins 1992, 40: 127–1251.
Sugar AM, Saunders C, Idelson BA, Bernard DB Interaction of fluconazole and cyclosporine. Annals of Internal Medicine 1989, 110: 844.
Graves NM, Mantas AJ, Hilligoss DM, Cannafax DM Fluconazole-cyclosporine interaction. Clinical Pharmacology and Therapeutics 1990, 47: 208.
Kronbach T, Fischer V, Meyer UA Cyclosporine metabolism in human liver: identification of a cytochrome P-4503III gene family as the major cyclosporine-metabolising enzyme explains interactions of cyclosporine with other drugs. Clinical Pharmacology and Therapeutics 1988, 43: 630–635.
Bienvenu T, Rey E, Pons G, D'Athis P, Oliver G A simple non-invasive procedure for the investigation of cytochrome P-450IIIA dependent enzymes in humans. International Journal of Clinical Pharmacology, Therapeutics and Toxicology 1991, 29: 441–445.
Sladek NE Metabolism of oxazaphosphorines. Pharmacology and Therapeutics 1988, 37: 301–355.
Chang TKH, Weber GF, Crespi CL, Waxman DJ Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Research 1993, 53: 5629–5637.
Walker D, Flinois JP, Monkman SC, Beloc C, Boddy AV, Cholerton S, Daly AK, Lind MJ, Pearson ADJ, Beaune PH, Idle JR: Identification of the major human hepatic cytochrome P-450 involved in activation and N-dechlorethylation of ifosfamide. Biochemical Pharmacology 1994, 47: 1157–1163.
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Yule, S.M., Walker, D., Pearson, A.D.J. et al. Potential inhibition of alkylating agent metabolism by fluconazole. Eur. J. Clin. Microbiol. Infect. Dis. 13, 1086–1087 (1994). https://doi.org/10.1007/BF02111837
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DOI: https://doi.org/10.1007/BF02111837