Skip to main content
SpringerLink
Log in

The inhibitory effect of pyrophosphate on calcium oxalate precipitation and its relation to urolithiasis

  • Kurze Mitteilungen
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Pyrophosphat in so kleinen Mengen wie 10−5 M erhöht wesentlich die minimale Konzentration von Calcium und Oxalat, welche zur Kristallbildung von Calciumoxalat nötig ist. Man kann daraus schliessen, dass das im Harn vorhandene Pyrophosphat durch seine kristallisationshemmende Eigenschaft zur Erklärung der urinären Übersättigung an Calcium und Oxalat beiträgt. Da es auch die Bildung von Calciumphosphat hemmt, vermuten wir, dass ihm eine wichtige Rolle in der Pathophysiologie der Urolithiase zukommt.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. J. E. Howard andW. C. Thomas, Trans. Amer. clin. climat. Ass.70, 94 (1958).

    Google Scholar 

  2. C. W. Vermeulen, E. S. Lyon, andG. H. Miller, J. Urol. (Baltimore)79, 596 (1958).

    Article  PubMed  CAS  Google Scholar 

  3. H. Fleisch andS. Bisaz, Amer. J. Physiol.203, 671 (1962).

    Article  PubMed  CAS  Google Scholar 

  4. H. Fleisch andS. Bisaz, Helv. physiol. Acta21, 88 (1963).

    CAS  Google Scholar 

  5. R. Reitemeyer andT. Bührer, J. physiol. Chem.44, 535 (1940).

    Article  Google Scholar 

  6. T. Bührer andR. Reitemeyer, J. physiol. Chem.44, 552 (1940).

    Article  Google Scholar 

  7. S. Otani, Bull. chem. Soc. Japan33, 1543 and 1549 (1960).

    Article  CAS  Google Scholar 

  8. M. Miura, S. Otani, M. Kodama, andK. Shinagawa, J. physiol. Chem.66, 252 (1962).

    Article  CAS  Google Scholar 

  9. H. Fleisch andW. F. Neuman, Amer. J. Physiol.200, 1296 (1961).

    Article  CAS  Google Scholar 

  10. H. Fleisch, Schweiz. med. Wschr.92, 1197 (1962).

    PubMed  CAS  Google Scholar 

  11. C. W. Vermeulen, E. S. Lyon, W. B. Gill, andW. H. Chapman, J. Urol. (Baltimore)82, 249 (1959).

    Article  PubMed  CAS  Google Scholar 

  12. J. E. Howard, Canad. med. Ass. J.86, 1001 (1962).

    PubMed  PubMed Central  CAS  Google Scholar 

  13. J. E. Howard, W. C. Thomas, T. Mukai, R. A. Johnston, andB. J. Pascoe, Trans. Ass. Amer. Phyens.75, 301 (1962).

    CAS  Google Scholar 

  14. H. Fleisch, S. Bisaz, andA. D. Care, Lancet, submitted.

Download references

Author information

Authors and Affiliations

  1. Laboratorium für experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Davos, Switzerland

    H. Fleisch & S. Bisaz

Authors
  1. H. Fleisch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Bisaz
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by the Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, by the U.S. Public Health Service Grant AM 07266-01 of the National Institute of Arthritis and Metabolic Diseases, and by the Sandoz-Stiftung zur Förderung der medizinisch-biologischen Wissenschaften. We should like to thank ProfessorH. Pfaendler, interpreter W.H.O., for correcting the manuscript.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fleisch, H., Bisaz, S. The inhibitory effect of pyrophosphate on calcium oxalate precipitation and its relation to urolithiasis. Experientia 20, 276–277 (1964). https://doi.org/10.1007/BF02151805

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02151805

Keywords

Search

Navigation