Abstract
Pentoxifylline (Trental, 5 mg/kg/h for 6 h) was administered to 17 premature infants with sepsis, on 3 successive days. A statistically significant decrease in mortality rate (P < 0.04) was observed in comparison to a retrospectively analysed group of 13 septic infants, who were treated in a comparative way but without the use of a pentoxifylline infusion. The suggestion that pentoxifylline may be an effective drug in the treatment of Gram-negative sepsis in premature infants should be tested in a double-blind, randomized study.
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Abbreviations
- TNF :
-
tumour necrosis factor-alpha
- PTXF :
-
pentoxifylline
References
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Lauterbach, R., Pawlik, D., Tomaszczyk, B. et al. Pentoxifylline treatment of sepsis of premature infants: Preliminary clinical observations. Eur J Pediatr 153, 672–674 (1994). https://doi.org/10.1007/BF02190690
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DOI: https://doi.org/10.1007/BF02190690