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Relative risk factors for osteoporotic fracture: A pilot study of the MEDOS questionnaire

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Summary

This study tested selected elements of a questionnaire devised to detect risk factors for osteoporosis in a large case-control study of hip fracture. The questions were applied to two separate studies. The first utilised a hospital sample of postmenopausal women with established vertebral osteoporosis, and responses were compared to woman with primary osteoarthritis. In a second study, the questionnaire was applied to apparently healthy women participating in a study of bone density. Significant differences between patients with osteoporosis and osteoarthritis were observed in body mass index, the prevalence of appendicular fractures, the degree of immobilisation, the age of menarche, exposure to sunlight and indices of physical activity. Significant differences were found in bone mass in healthy women divided according to the age of menarche, parity and duration of lactation. These data identify previously established risk factors for osteoporosis and suggest that the MEDOS questionnaire will provide a powerful tool for the future assessment of risk factors in osteoporosis.

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Authors and Affiliations

  1. Arthritis and Metabolic Bone Disease Research Unit, K.U. Leuven, 3212, Pellenberg, Belgium

    J. Dequeker, L. Tobing, V. Rutten & P. Geusens

Authors
  1. J. Dequeker
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  2. L. Tobing
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  3. V. Rutten
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  4. P. Geusens
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Consortia

MEDOS Study Group

Additional information

Collaborating centers: Dilşen G., Istanbul; Gennari C., Siena; Lopez Vaz A.A., Porto; Lyritis G., Athens; Mazzuoli G.D., Rome; Miravet L., Paris; Passeri M., Parma; Perez Cano R., Sevilla; Rapado A., Madrid; Ribot C., Toulouse.

Project group: Allander E., WHO Collaborating Centre for the Epidemiology of Rheumatic Conditions, Huddinge; Dequeker J., WHO Consultant, Leuven; Gonzalez A., Sandoz, Basle; Kanis J.A., European Osteoporosis Foundation, Sheffield; Keen D., Sandoz, Basle; Khaltaev N., WHO Non-communicable Diseases, Geneva; Plüss M., Sandoz, Basle.

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Dequeker, J., Tobing, L., Rutten, V. et al. Relative risk factors for osteoporotic fracture: A pilot study of the MEDOS questionnaire. Clin Rheumatol 10, 49–53 (1991). https://doi.org/10.1007/BF02208033

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  • DOI: https://doi.org/10.1007/BF02208033

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