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CD4+ and CD8+ subsets: Naive and memory cells in the peripheral blood of patients with systemic sclerosis

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Summary

Systemic Sclerosis (SSc; scleroderma) is associated with several immunological abnormalities, including altered proportion between lymphocyte subsets. Peripheral blood lymphocyte subsets from 25 patients with SSc were studied by two-colour flow cytometry using monoclonal antibodies against CD45RA and CD29 markers, which allow a dissection of CD4+ and CD8+ populations into ‘naive’ and ‘memory’ subsets. A decrease of the percentage of CD8+ (p<0.05) and of CD8+ CD29+ (p<0.001) cells was observed compared to that in 20 age and sex-matched controls. These abnormalities were not significantly associated with the extension of cutaneous disease or other clinical features of SSc nor with treatment, pattern of autoantibodies or HLA phenotype.

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Authors and Affiliations

  1. Servizio di Immunologia Clinica, Spedali Civili di Brescia, P. le Spedali Civili, 1, 25100, Brescia, Italy

    R. Gorla,  P. Airo', A. Malagoli, G. Carella, E. Prati, D. Brugnoni, F. Franceschini & R. Cattaneo

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  1. R. Gorla
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  2. P. Airo'
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  3. A. Malagoli
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  4. G. Carella
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  5. E. Prati
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  6. D. Brugnoni
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  7. F. Franceschini
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  8. R. Cattaneo
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Gorla, R., Airo', P., Malagoli, A. et al. CD4+ and CD8+ subsets: Naive and memory cells in the peripheral blood of patients with systemic sclerosis. Clin Rheumatol 13, 83–87 (1994). https://doi.org/10.1007/BF02229871

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  • DOI: https://doi.org/10.1007/BF02229871

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