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Blockade of ovarian compensatory hypertrophy and ovulation in the rat by hypothalamic implants of an anticholinergic drug

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Summary

In order to confirm the participation of a central cholinergic system in the control of hypophysial folliculotrophin release, implants of atropine (250 micrograms) were performed in different hypothalamic areas.

In hemicastrated animals, the ovarian compensatory hypertrophy was prevented by the drug without disturbance in the estrous cycle.

In contrast, in intact animals, prolonged diestrus was observed, with a decrease in the ovarian weight.

These effects, induced by pharmacological blockade, confirm the participation of a central cholinergic system in the control of hypophysial gonadotrophin release.

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Author notes

  1. M. A. Sala

    Present address: Departamento de Patología y Fisiopatología, Laboratorio de Neuroendocrinología, Hospital de Clínicas, piso 16, Montevideo, Uruguay

Authors and Affiliations

  1. Laboratory of Neuroendocrinology, Department of Pathology, Faculty of Medicine, Montevideo, Uruguay

    M. A. Sala, J. T. Otegui, W. L. Benedetti, J. M. Monti & E. Grinó

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  1. M. A. Sala
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  2. J. T. Otegui
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  3. W. L. Benedetti
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  4. J. M. Monti
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  5. E. Grinó
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Sala, M.A., Otegui, J.T., Benedetti, W.L. et al. Blockade of ovarian compensatory hypertrophy and ovulation in the rat by hypothalamic implants of an anticholinergic drug. J. Neuro-Viscer. Relat 32, 241–248 (1971). https://doi.org/10.1007/BF02239133

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  • DOI: https://doi.org/10.1007/BF02239133

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