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Modality dependent changes in event-related potentials correlate with specific cognitive functions in nondemented patients with Parkinson's disease

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Journal of Neural Transmission - Parkinson's Disease and Dementia Section

Summary

The relationship between event-related potentials (ERPs) and cognitive functioning was studied in patients with Parkinson's Disease (PD) but without dementia. Auditory and visual stimuli were used; 30 subjects participated in the auditory study and 20 in the visual study. Patient groups did not differ with respect to gender, age, education, illness duration, and level of cognitive functioning. Visual stimuli were 2.3 cpd sinusoidal grating patterns randomly presented in an oddball paradigm (oblique vs. vertical spatial orientation). Auditory stimuli were tones presented at 70dB SPL at a rate of 1.1/second, also using the oddball paradigm (1.5K vs. 1K tones). All patients were given neuropsychological tests to measure verbal fluency, memory, visual spatial perception, and abstract reasoning. P300 and N200 abnormalities correlated with a number of these measures, such that longer ERP latencies were related to lower scores on tests of cognitive functioning. Patterns of results suggest that auditory and visual ERPs correlate with different subsets of neuropsychological functions in nondemented PD patients and that N200 may provide a new metric for clinical use.

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Author notes

  1. I. Bodis-Wollner M.D., D.Sc.

    Present address: Department of Neurology, SUNY Health Science Center at Brooklyn, 450 Clarkson Avenue, Box 1213, 11203, Brooklyn, NY, USA

Authors and Affiliations

  1. Department of Neurology and the Clinical Center for Research in Parkinson's Disease, Mount Sinai School of Medicine, City University of New York, USA

    I. Bodis-Wollner M.D., D.Sc., J. C. Borod, B. Cicero, C. S. Haywood, L. Mylin, A. Falk & M. D. Yahr

  2. Department of Psychology, Queens College, City University of New York, USA

    J. C. Borod, B. Cicero & C. S. Haywood

  3. Department of Psychology, Trinity College, Hartford, CT, USA

    S. Raskin

  4. Department of Neurology, Albert Einstein School of Medicine, Bronx, NY, USA

    M. Sliwinski

  5. Department of Otolaryngology, New York Eye and Ear Infirmary and New York Medical College, USA

    A. Falk

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  1. I. Bodis-Wollner M.D., D.Sc.
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Bodis-Wollner, I., Borod, J.C., Cicero, B. et al. Modality dependent changes in event-related potentials correlate with specific cognitive functions in nondemented patients with Parkinson's disease. J Neural Transm Gen Sect 9, 197–209 (1995). https://doi.org/10.1007/BF02259661

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  • DOI: https://doi.org/10.1007/BF02259661

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