Abstract
The aim of this study was to characterise brain tumour type and treatment response in relation to the uptake of thallium-201.201Tl single photon emission tomography (SPET) was performed in 58 patients with brain tumours. Fifty-six patients were utilised for the statistical comparison of the early and delayed201Tl indices expressed as the ratio of tumour to contralateral cerebral hemisphere uptake. The retention index of201Tl in the tumour tissue calculated from the early and delayed scans was also analysed. Furthermore, in 56 patients with 58 brain tumours, a comparison was made of the diagnostic value of high201Tl uptake and gadolinium diethylene triamine penta-acetic acid (Gd-DTPA) enhancement on MRI scans. Although high201Tl uptake was observed in viable malignant gliomas, brain metastases, meningiomas and malignant teratoma, the viable malignant gliomas could not be differentiated from brain metastases and extracerebral tumours by means of201Tl indices.201Tl SPET failed to diagnose a viable ring-enhanced tumour with a thin rim and small tumours of less than 1.5 cm in diameter visualised by Gd-DTPA-enhanced MRI. In spite of this,201Tl SPET appears to be effective for determination of the malignant viability of tumours
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Yoshii, Y., Satou, M., Yamamoto, T. et al. The role of thallium-201 single photon emission tomography in the investigation and characterisation of brain tumours in man and their response to treatment. Eur J Nucl Med 20, 39–45 (1993). https://doi.org/10.1007/BF02261244
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DOI: https://doi.org/10.1007/BF02261244