Abstract
The diagnosis and evaluation of perinatal asphyxia can be problematic and objective means of assessing its severity are lacking. To study the validity of urinary uric acid as a marker of the degree of perinatal asphyxia, the ratio of urinary uric acid to creatinine (UA/Cr) in urine specimens obtained after birth was measured in two groups of infants. Eighteen term infants with Apgar scores ≤ 5 at 5 min and/or an umbilical cord blood pH ≤ 7.2, and a base deficit ≽ 12 meq/1 were compared to 50 healthy controls. The severity of the perinatal asphyxia was determined by using an ASPHYXIA SCORE. The UA/Cr was higher in the asphyxiated group when compared to controls. (2.06 ± 1.12, vs. 0.64 ± 0.48;P < 0.001). Within the perinatal asphyxia group, a significant correlation was found between the UA/Cr ratio and the asphyxia score. (r = 0.86,P < 0.01).
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Abbreviations
- UA/CR :
-
uric acid/creatinine
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Bader, D., Gozal, D., Weinger-Abend, M. et al. Neonatal urinary uric acid/ceratinine ratio as an additional marker of perinatal asphyxia. Eur J Pediatr 154, 747–749 (1995). https://doi.org/10.1007/BF02276720
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DOI: https://doi.org/10.1007/BF02276720