Abstract
1|Objective and Design The anti-inflammatory activity of topically applied nimesulide gel was compared in different experimental models with that of diclofenac and piroxicam gels.
2|Material Wistar albino rats of either sex were used.
3|Treatment
In acute models, 50 mg of nimesulide or diclofenac were applied to right hind paws 1 h (carrageenan) or immediately before (formalin) irritant injection (sub-plantar). In adjuvant arthritis, 50 mg of nimesulide, diclofenac or piroxicam were applied daily to injected paws for 14 days.
4|Methods Paw volume was measured by plethysmograph. Statistical significance was tested with Student's t-test.
5|Results In the carrageenan paw odema, topical nimesulide gel exhibited similar anti-inflammatory activity to diclofenac gel, and was more effective than diclofenac gel in formalin-paw odema. In both acute (18h) and chronic (14d) phases of adjuvant arthritis, nimesulide gel was more effective than diclofenac or piroxicam gels.
6|Conclusion Topical nimesulide gel possesses higher anti-inflammatory activity than that of diclofenac or piroxicam gels.
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accepted by M. J. Parnham
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Gupta, S.K., Prakash, J., Awor, L. et al. Anti-inflammatory activity of topical nimesulide gel in various experimental models. Inflamm Res 45, 590–592 (1996). https://doi.org/10.1007/BF02312040
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DOI: https://doi.org/10.1007/BF02312040