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Cortical bone senescence and mineral bone density of the humerus

  • Clinical Investigations
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Summary

Study of the humeral cortex of 89 acute cadavers showed that an important factor contributing to the physiologic bone loss of aging is increasing bone porosity. Mean cortical porosity increases in both sexes with age, from 4.6% in men and 4% in women at 40 years of age to 10% and more at age 80. In the population studied, no significant difference of porosity was observed between men and women. Apparent mineral density is linked to porosity, and decreases markedly with age in women. Changes in men are lesser in magnitude and show a larger difference of density values. Correction of the apparent mineral density, by a factor reflecting the proportion of vascular and resorption spaces in the cortical bone, produces a true mineral density which does not vary significantly with age in either sex. The density values obtained for the proximal humerus differ from those in the literature which represent the femur. However, they are more readily compared with the results of clinical densitometry and may have greater clinical applications.

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References

  1. Garn SM (1970) The earlier gain and the later loss of cortical bone. C. C. Thomas, Springfield

    Google Scholar 

  2. Dequeker J (1980) Measurement of bone mass and bone remodelingin vivo: Value of the radiogrammetric approach. Acta Rhum 4:40–75

    Google Scholar 

  3. Virtama P, Helelä T (1969) Radiographic measurements of cortical bone. Acta Radiol (Suppl 293) Stockholm

  4. Bloom RA (1980) A comparative estimation of the combined cortical thickness of various bone sites. Skeletal Radiol 5:167–170

    Article  CAS  PubMed  Google Scholar 

  5. Bernard J, Laval-Jeantet M (1962) L'épaisseur relative de la corticale du tibia: Application à l'évaluation des ostéoporoses et des ostéoscléroses. Presse Méd 70:889–890

    CAS  PubMed  Google Scholar 

  6. Jowsey J (1960) Age changes in human bone. Clin Orthop 17:210–218

    Google Scholar 

  7. Atkinson PJ (1965) Changes in resorption spaces in femoral cortical bone with age. J Pathol Bact 89:173–178

    Article  CAS  Google Scholar 

  8. Martin RB, Pickett JC, Zinaich S (1980) Studies of skeletal remodeling in aging men. Clin Orthop 149:268–282

    PubMed  Google Scholar 

  9. Laval-Jeantet AM, Goldman S, Laval-Jeantet M (1977) Densitométrie osseuse de précision sur films sans écrans. J Radiol Electrol 58:63–68

    CAS  PubMed  Google Scholar 

  10. Laval-Jeantet AM, Chateau JY, Bergot C, Laval-Jeantet M, Kuntz D (1981) Comparaison de la radiodensitométrie et de l'histomorphométrie dans l'étude de l'os normal et pathologique. Pathol Biol 29:155–161

    CAS  PubMed  Google Scholar 

  11. Bloom RA, Laws JW (1970) Humeral cortical thickness as an index of osteoporosis in women. Br J Radiol 43:522–527

    Article  CAS  PubMed  Google Scholar 

  12. Meunier A, Dallant P, Christel P, Sedel L (1983) A microcomputer laboratory technic to quantify cortical bone microstructure. 29th Annual ORS Anaheim California, March 8–10 1983

  13. Jowsey J (1968) Age and species differences in bone. Cornell Vet 57 (Suppl Jan) 74–94

    Google Scholar 

  14. Currey JD (1964) Some effects of ageing in human haversian systems. J Anat London 98:69–75

    CAS  Google Scholar 

  15. Singh M, Gunberg DL (1970) Estimation of age at death in human males from quantitative histology of bone fragments. Am J Phys Anthrop 33:373–382

    Article  CAS  PubMed  Google Scholar 

  16. Thompson DD (1980) Age changes in bone mineralization, cortical thickness, and haversian canal area. Calcif Tissue Int 31:5–11

    CAS  PubMed  Google Scholar 

  17. Atkinson PJ, Weatherell JA (1967) Variation in the density of the femoral diaphysis with age. J Bone Joint Surg 49B:781–788

    Google Scholar 

  18. Bergot C, Bocquet JP (1976) Etude systématique en fonction de l'âge de l'os spongieux et de l'os cortical de l'humérus et du fémur. Bull Mém Soc Anthropol Paris, 3 (Série XIII):215–242

    Article  Google Scholar 

  19. Lindahl O, Lindgren A (1967) Cortical bone in man. I. Variation of the amount and density with age and sex. Acta Orthop Scand 38:133–140

    Article  CAS  PubMed  Google Scholar 

  20. Arnold JS (1970) Focal excessive endosteal resorption in aging and senile osteoporosis. In: Barzel US (ed) Osteoporosis. Grune & Stratton, New York, pp 80–100

    Google Scholar 

  21. Bergot C, Prêteux F, Mark AS, Laval-Jeantet AM, Serra J (1982) Automatic analysis of microradiographs: Porosity of humeral cortical bone during aging. In: Silbermann M, Slavkin HC (eds) Current advances in skeletogenesis. Excerpta Medica, Amsterdam, pp 490–497

    Google Scholar 

  22. Baud CA (1968) Submicroscopic structure and functional aspects of the osteocyte. Clin Orthop 56:227–236

    CAS  PubMed  Google Scholar 

  23. Black J, Mattson RU (1982) Relationship between porosity and mineralization in the haversian osteon. Calcif Tissue Int 34:332–336

    CAS  PubMed  Google Scholar 

  24. Boyde A (1980) Evidence against “osteocytic osteolysis.” In: Jee WSS, Parfitt AM (eds) Bone histomorphometry. Suppl to Metab Bone Dis Rel Res, S.N.P.M.D., Paris, pp 239–255

    Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Radiologie Expérimentale, Université Paris VII, 10 avenue de Verdun, 75010, Paris, France

    Anne-Marie Laval-Jeantet, Catherine Bergot, Roberta Carroll & Françoise Garcia-Schaefer

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  1. Anne-Marie Laval-Jeantet
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  2. Catherine Bergot
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  3. Roberta Carroll
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  4. Françoise Garcia-Schaefer
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Laval-Jeantet, AM., Bergot, C., Carroll, R. et al. Cortical bone senescence and mineral bone density of the humerus. Calcif Tissue Int 35, 268–272 (1983). https://doi.org/10.1007/BF02405044

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