Abstract
We report the successful management of recurrent ventricular tachycardias in a newborn suffering from an intracardiac tumor. Amiodarone was the only agent able to control the tachycardias and did so as long as an individually titrated plasma concentration above 0.8 μmol/L was maintained. Because no therapeutic plasma concentration has been defined in children and no kinetic studies are available in this population, we optimized the dosing regimen based on a computer simulation, taking into account the pharmacokinetic parameters of the patient and the individual concentration-effect relation.
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Bouillon, T., Schiffmann, H., Bartmus, D. et al. Amiodarone in a newborn with ventricular tachycardia and an intracardiac tumor: Adjusting the dose according to an individualized dosing regimen. Pediatr Cardiol 17, 112–114 (1996). https://doi.org/10.1007/BF02505094
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DOI: https://doi.org/10.1007/BF02505094