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Iron therapy resistant microcytic anaemia in a 13-year-old girl with Castleman disease

  • Hematology/Oncology
  • Published:
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Abstract

Abstract

We describe the case history of a 13-year-old girl with chronic fatigue and prolonged microcytic anaemia. She received oral iron since the age of 11 but failed to respond to it. Laboratory studies revealed elevated C-reactive protein and hypergammaglobulinaemia. A large solitary mesenterial lymph node could be demonstrated by ultrasonography and CT. A diagnosis of Castleman disease was suspected and confirmed histologically. After surgical removal of the lymphoma the patient recovered completely.

Conclusion

Castleman disease should be considered in cases of chronic fatigue, unexplained fever, microcytic anaemia and hypergam-maglobulinaemia.

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Abbreviations

CRP :

C-reactive protein

ESR :

erythrocyte sedimentation rate

HV :

hyaline-vascular type of Castleman disease

Il-6 :

interleukin-6

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Authors and Affiliations

  1. Hospital Centre Apeldoorn, The Netherlands

    T. A. De Heer-Groen

  2. Riyadh Armed Forces Hospital, Kingdom of Saudi Arabia

    P. J. van Dijken

  3. ‘Het Wilhelmina Kinderziekenhuis’, University Hospital for Children and Youth, P.O. BOX 18009, 3501 CA, Utrecht, The Netherlands

    A. B. J. Prakken & N. M. A. Bax

Authors
  1. T. A. De Heer-Groen
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  2. A. B. J. Prakken
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  3. N. M. A. Bax
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  4. P. J. van Dijken
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De Heer-Groen, T.A., Prakken, A.B.J., Bax, N.M.A. et al. Iron therapy resistant microcytic anaemia in a 13-year-old girl with Castleman disease. Eur J Pediatr 155, 1015–1017 (1996). https://doi.org/10.1007/BF02532521

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  • DOI: https://doi.org/10.1007/BF02532521

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