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Percutaneous injection sclerotherapy with minocycline hydrochloride for simple renal cysts

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Abstract

Minocycline hydrochloride as a sclerosant for the treatment of simple renal cysts was evaluated. Cyst puncture was performed, and minocycline hydrochloride solution for intravenous administration was injected after aspiration. Of 154 cysts evaluated by ultrasound after 3 months or more, 69 were no longer demonstrable, 49 showed 50% or greater reduction in the maximum cyst diameter, and only 8 were unchanged or slightly increased in size. In constrast, only 1 of 20 cysts aspirated without minocycline hydrochloride injection (controls) showed 50% or greater reduction after 3 months. There was a significant difference in the reduction rates between the minocycline-treated group and control group (p<0.01). These results suggest that minocycline hydrochloride is an effective sclerosant to treat simple renal cysts.

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References

  1. van der Ent, C. K., van Dalen A., Enterman J.H.: Antibiotic sclerotherapy for renal cysts.Fortschr. Röntgenstr., 150, 339 (1989).

    Google Scholar 

  2. Zachrisson, L.: Simple renal cysts treated with bismuth phosphate at the diagnostic puncture.Acta Radiol. Diagn., 23, 209 (1982).

    CAS  Google Scholar 

  3. Holmberg, G., Hietala, S-O., Ljungberg, B.: A comparison of radiologic methods in the diagnosis of renal mass lesions.Scand. J. Urol. Nephrol., 22, 187 (1988).

    PubMed  CAS  Google Scholar 

  4. Pollack, H. M., Banner, M. P., Arger, P. H., Peters, J., Mulhern, C. B. Jr., Coleman, B. G.: The accuracy of gray-scale renal ultrasonography in differentiating cystic neoplasms from benign cysts.Radiology, 143, 741 (1982).

    PubMed  CAS  Google Scholar 

  5. Grabstald, H: Catheterization of renal cyst for diagnostic and therapeutic purposes.J. Urol., 71, 28 (1954).

    PubMed  CAS  Google Scholar 

  6. Pearman, R. O.: Percutaneous needle puncture and aspiration of renal cysts: A diagnostic and therapeutic procedure.J. Urol., 96, 139 (1966).

    Google Scholar 

  7. Raskin, M. M., Poole, D. O., Roen, S. A., Viamonte, M. Jr.: Percutaneous management of renal cysts: Results of a four-year study.Radiology, 115, 551 (1975).

    PubMed  CAS  Google Scholar 

  8. Vestby, G. W.: Percutaneous needle puncture of renal cysts: New method in therapeutic management.Invest. Radiol., 2, 449 (1967).

    Article  PubMed  CAS  Google Scholar 

  9. Bean, W. J.: Renal cysts: Treatment with alcohol.Radiology, 138, 329 (1981).

    PubMed  CAS  Google Scholar 

  10. Gernert, J. E., Stein, J., Bischoff, A. J.: Solitary renal cysts: Experience with 100 cases.J. Urol., 100, 251 (1968).

    PubMed  CAS  Google Scholar 

  11. Steg, A.: Renal cysts. II. Chemical and dynamic study of cyst fluid.Eur. Urol., 2, 164 (1976).

    PubMed  CAS  Google Scholar 

  12. Ohkawa, M., Motoi, I., Hirano, S., Okasho, A., Hisazumi, H.: Biochemical and pharmacodynamic studies of simple renal cyst fluid in relation to infection.Nephron, 59, 80 (1991).

    PubMed  CAS  Google Scholar 

  13. Rubinson, R. M., Bolooki, H.: Intrapleural tetracycline for control of malignant plenural effusion: A preliminary report.South. Med. J., 65, 847 (1972).

    PubMed  CAS  Google Scholar 

  14. Benz, R. L., Schleifer, C.R.: Hydrothorax in continuous ambulatory peritoneal dialysis: Successful treatment with intrapleural tetracycline and a review of the literature.Am. J. Kidney Dis., 5, 136 (1985).

    PubMed  CAS  Google Scholar 

  15. Edmonds, C. J., Tellez, M.: Treatment of thyroid cysts by aspiration and injection of sclerosant.Br. Med. J., 295, 529 (1987).

    CAS  Google Scholar 

  16. Davis, S., Sharma, S. M., Blumberg, E. D., Kim, C. S.: Intrapericardial tetracycline for the management of cardiac tamponade secondary to malignant pericardial effusion.N. Engl. J. Med., 299, 1113 (1978).

    Article  PubMed  CAS  Google Scholar 

  17. Levine, L. A., DeWolf, W. C.: Aspiration and tetracycline sclerotherapy of hydroceles.J. Urol., 139, 959 (1988).

    PubMed  CAS  Google Scholar 

  18. von Wernecke, K. Heckemann, R., Rehwald, U.: Therapeutische Ergebnisse der ultraschallgeführten Nierenzystenpunktion.Fortschr. Röntgenstr. 143, 553 (1985).

    Article  CAS  Google Scholar 

  19. Macdonald, H., Kelly, R. G., Allen, E. S., Noble, J. F., Kanegis, L. A.: Pharmacokinetic studies on minocycline in man.Clin. Pharmacol. Ther., 14, 852 (1983).

    Google Scholar 

  20. Carney, S., Butcher, R. A., Dawborn, J. K., Pattison, G.: Minocycline excretion and distribution in relation to renal function in man.Clin. Exp. Pharmacol. Physiol., 1, 299 (1974).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, School of Medicine, Kanazawa University, Kanazawa, Japan

    M. Ohkawa & S. Tokunaga

  2. Department of Urology, Naruwa Insurance Hospital, Kanazawa, Japan

    M. Orito

  3. Department of Urology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan

    M. Shimamura

  4. Department of Urology, Kouseiren Takaoka Hospital, Takaoka, Japan

    S. Hirano

  5. Department of Urology, Maizuru Kyohsai Hospital, Maizuru, Japan

    A. Okasho & S. Kosaka

Authors
  1. M. Ohkawa
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  2. S. Tokunaga
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  3. M. Orito
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  4. M. Shimamura
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  5. S. Hirano
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  6. A. Okasho
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  7. S. Kosaka
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Ohkawa, M., Tokunaga, S., Orito, M. et al. Percutaneous injection sclerotherapy with minocycline hydrochloride for simple renal cysts. International Urology and Nephrology 25, 37–43 (1993). https://doi.org/10.1007/BF02552252

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  • DOI: https://doi.org/10.1007/BF02552252

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