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Treatment of psoriasis vulgaris by oral administration of 1α-hydroxyvitamin D3—Open-design study

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Summary

In an open-design study 1α-hydroxyvitamin D3 was administered orally to 17 patiens with psoriasis vulgaris at a dose of 1.0 μg/day for 6 months. More than moderate improvement was observed in 13 (76 %) of the 17 patients from 2.7±0.6 months (mean±SD) after the start of treatment. No side effects of the treatment were observed. The mechanism of the effect of 1α-hydroxyvitamin D3 requires study, but these data suggest that its oral administration is effective for treatment of psoriasis vulgaris.

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Authors and Affiliations

  1. Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku, 553, Osaka, Japan

    S. Morimoto, S. Imanaka, K. Fukuo, E. Koh, T. Onishi & Y. Kumahara

  2. Department of Dermatology, Osaka University Medical School, Fukushima-ku, 553, Osaka, Japan

    K. Yoshikawa, T. Kozuka & Y. Kitano

Authors
  1. S. Morimoto
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  2. K. Yoshikawa
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  3. T. Kozuka
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  4. Y. Kitano
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  5. S. Imanaka
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  6. K. Fukuo
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  7. E. Koh
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  8. T. Onishi
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  9. Y. Kumahara
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Morimoto, S., Yoshikawa, K., Kozuka, T. et al. Treatment of psoriasis vulgaris by oral administration of 1α-hydroxyvitamin D3—Open-design study. Calcif Tissue Int 39, 209–212 (1986). https://doi.org/10.1007/BF02555120

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  • DOI: https://doi.org/10.1007/BF02555120

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