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Prolonged survival following palliative renal tumor embolization by capillary occlusion

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Abstract

Nine patients with renal cell carcinoma and severe hematuria were palliatively treated with a new type of angioocclusion: The concept of capillary embolization. The so-called occlusion gel Ethibloc was used as embolizing agent. Each patient was followed up until death or for at least 4 years. All patients had a stage T3 or T4 tumor, 3 patients had metastases to multiple organs, 3 had lung metastases, and 3 were free of metastatic disease. In all cases, very high volumes (14–40 ml) of the embolizing agent were necessary to achieve total occlusion of the entire arterial compartment. Patients without metastatic disease had a mean survival time of 6 years and 4 months, all of them without signs of malignant disease. Patients with metastases had a mean survival time of 3 years. Compared with the natural history of renal cell carcinoma treated otherwise, this represents a substantial prolongation of survival time. Contrary to other angioocclusive treatment modalities, the concept of capillary occlusion with Ethibloc seem to achieve total tumor destruction.

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References

  1. Raßweiler J, Kauffmann GW, Rohrback R, Richter GM (1980) Kapilläre Embolization, Teils 1: Verschluß des gesamten arteriellen Gefäßsystems der gesunden Rattenniere. Fortschr Röntgenstr 133:644–653

    Google Scholar 

  2. Richter GM, Rohrback R, Kauffmann GW, Raßweiler J (1981) Kapilläre Embolisation, Teil 2. Verschluß des gesamten arteriellen Gefäßsystems experimentell erzeugter Nierentumoren. Fortschr Röntgenstr 135:85–97

    CAS  Google Scholar 

  3. Kauffmann GW, Richter GM, Raßweiler J, Rohrback R (1982) New topics in embolization. In: Baert AL, Boijsen E, Fuchs WA, Heuck FHW (eds) Frontiers of European radiology 1. Springer, Berlin Heidelberg New York pp 72–99

    Google Scholar 

  4. Kauffmann GW, Raßweiler J, Richter G, Hauenstein KH, Rohrbach R, Friedburg H (1981) Capillary embolization of Ethibloc. New embolization concept tested in dog kidney. AJR 137:1163–1168

    PubMed  CAS  Google Scholar 

  5. Kauffmann GW, Richter GM (1986) Palliative capillary embolization in renal carcinoma. Ann Radiol 29:205–207

    PubMed  CAS  Google Scholar 

  6. Hlava A, Steinhart L, Navratil P (1976) Intraluminal obliteration of the renal arteries in kidney tumors. Radiology 121:323–329

    Google Scholar 

  7. Steckenmesser R, Bayindir S, Rothauge CF, Nöske K, Weidner W (1976) Embolisation maligner Nierentumoren. Fortschr Röntgenstr 125:251–257

    CAS  Google Scholar 

  8. Marberger M, Georgi M (1977) Ballon occlusion of the renal artery in tumor nephrectomy. J Urol 114:360–363

    Google Scholar 

  9. Haertel M, Zaunbauer W, Zingg E (1977) Die Katheterembolisation maligner urologischer Tumoren. Schweiz Med Wochenschr. 107:584–588

    PubMed  CAS  Google Scholar 

  10. Frasson F, Fugazzola C, Bianchi G, Franzolin N, Caresano A, Del Favero C, Comelli S (1978) Selective arterial embolization in renal tumors. Radiol Clin Biol (Basel) 47:239–251

    CAS  Google Scholar 

  11. Müller JHA, Engel D, Waigand J, Mebel M (1978) Spätergebnisse nach palliativer Gafäßembolisierung bei inoperablen Nierentumoren (vorläufige Mitteilung). Z Urol Nephrol 71:481–490

    PubMed  Google Scholar 

  12. Riedl P, Flamm J (1979) Kontrollangiographische Befunde nach palliativer Nierenarterienokklusion mit der GAW-(Gianturco, Anderson, Wallace-). Spirale. Fortschr Röntgenstr 130:398–403

    CAS  Google Scholar 

  13. MacErlean DP, Owens AP, Bryan PJ (1980) Hypernephroma embolization—is it worthwhile? Clin Radiol 31:297–300

    Article  PubMed  CAS  Google Scholar 

  14. Frasson F, Roversi RA, Simonetti G, Ziviello M (1981) Embolization of renal tumors. A survey of the Italian experience: 282 patients. Ann Radiol 24:396–399

    PubMed  CAS  Google Scholar 

  15. Günther R, Klose K, Thelen M, Jacobi G (1981) Superselektive Embolisationen mit Gewebekleber am Urogenitaltrakt. Fortschr Röntgenstr 134:536–539

    Article  Google Scholar 

  16. Marx FJ, Chaussy CH, Moster E (1982) Grenzen und Gefahren der palliativen Embolisation inoperabler Nierentumoren. Urologe A 21:206–210

    PubMed  CAS  Google Scholar 

  17. Rassweiler J, Richter GM, Kauffmann GW, Wenz W (1985) Central, peripheral and capillary embolization tested in experimental renal tumors: New aspects for angioinfarction. J Urol 133:339A

    Google Scholar 

  18. Almgard LE, Slezak P (1977) Treatment of renal adenocarcinoma by embolization. A follow-up of 38 cases. Eur Urol 3:279–281

    PubMed  CAS  Google Scholar 

  19. Wolf KJ (1979) Therapeutische Embolisation von Organarterien-tierexperimentelle Untersuchungen, erste klinische Erfahrungen, Einführung eines neuen Embolisationsmaterials. Teil II. Fortschr Röntgenstr 131:511–519

    Article  CAS  Google Scholar 

  20. Wallace S, Chuang VP, Swanson D, Bracken B, Hersh EM, Ayala A, Johnson D (1981) Embolization of renal carcinoma. Experience with 100 patients. Radiology 138:563–570

    PubMed  CAS  Google Scholar 

  21. Ellman BA, Parkhill BJ, Curry TS, Marcus PB, Peters PC (1981) Ablation of renal tumors with absolute ethanol: A new technique. Radiology 141:619–626

    PubMed  CAS  Google Scholar 

  22. Mostofi FK (1967) Pathology and spread of renal cell carcinoma. In: King JS Jr (ed) Renal neoplasia. Little Brown and Co, Boston

    Google Scholar 

  23. O'dea MJ, Zincke H, Utz DC, Bernatz PE (1978) The treatment of renal cell carcinoma with solitary metastasis. J Urol 120:540–542

    PubMed  Google Scholar 

  24. DeKernion JB (1983) Treatment of advanced renal cell carcinoma— traditional methods and innovative approaches. J Urol 130:2–7

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Diagnositic Radiology, University of Freiburg, Germany

    Goetz Martin Richter & Werner Wenz

  2. Department of Pathology, University of Freiburg, Germany

    Rolf Rohrbach

  3. Department of Diagnostic Radiology, Radiological Clinic, Ruprecht-Karls University Heidelberg, Im Neuenheimer Feld 110, D-6900, Heidelberg, West Germany

    Guenter Werner Kauffmann

Authors
  1. Guenter Werner Kauffmann
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  2. Goetz Martin Richter
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  3. Rolf Rohrbach
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  4. Werner Wenz
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Kauffmann, G.W., Richter, G.M., Rohrbach, R. et al. Prolonged survival following palliative renal tumor embolization by capillary occlusion. Cardiovasc Intervent Radiol 12, 22–28 (1989). https://doi.org/10.1007/BF02577121

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