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Biochemical diagnosis of liver disease

  • Special Section on Current Concepts on Some Aspects of Clinical Chemistry
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Abstract

It is important that clinicians and laboratorians, including clinical chemists and pathologists, recognize and understand the clinical significance of abnormal liver function tests. The liver regulates many important metabolic functions. Hepatic injury is associated with distortion of these metabolic functions. Hepatic disease can be evaluated and diagnosed by determining serum concentrations of a number of serum analytes. Many serum analytes exist to assist in the biochemical diagnosis of liver disease. The focus of this paper is on the analytes which are associated with hepatic necrosis, cholestasis, defects in excretion and end stage hepatic disease which results in decreased synthetic function. The abnormalities of these serum analytes will be correlated with the important types of liver disease.

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  1. Department of Pathology, University of California and Veteran's Administration Medical Centers, 200 W. Arbor Dr., 92103, San Diego, California, USA

    Paul L. Wolf

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Wolf, P.L. Biochemical diagnosis of liver disease. Indian J Clin Biochem 14, 59–90 (1999). https://doi.org/10.1007/BF02869152

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