Summary
To investigate the expression of hypoxia inducible factor 1-alpha (HIF-1α) and its correlation with P53 and vascular endothelial growth factor (VEGF), immunohistochemical technique was employed to detect the protein expressions of HIF-1α, P53 and VEGF in specimens from 57 patients with lung cancer. The results indicated that the total positive proportion of HIF-1α expresion was 63% and the HIF-1α expression was more frequent in bronchiole-alveolar carcinoma (86%) than in other lung cancer. There was a strong association of HIF-1α with VEGF and P53 protein expressions. It is concluded that HIF-1α overexpression is a common event in lung cancer, which may be related to the up-regulation of the angiogenic factor VEGF and oncogene mutant P53 protein.
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ZHANG Huilan, female, born in 1976, M.D., Ph.D.
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Huilan, Z., Zhenxiang, Z., Yongjian, X. et al. The expression of hypoxia inducible factor 1-alpha in lung cancer and its correlation with P53 and VEGF. Current Medical Science 24, 124–127 (2004). https://doi.org/10.1007/BF02885408
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DOI: https://doi.org/10.1007/BF02885408