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No association between polymorphisms of the DNA repair geneXRCC1 and cervical neoplasm risk

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Environmental Health and Preventive Medicine Aims and scope

Abstract

Objectives

To investigate the association between genetic polymorphisms ofX-ray repair crosscomplementing group 1 (XRCC1) codons 194, 280, and 399 and cervical neoplasm susceptibility.

Methods

A community-based nested case-control study was conducted. The study population consisted of women living in Chiayi City, located in southwestern Taiwan, who had received pap smear screening between October, 1999, and December, 2000 (n=32,466). The potential cases were women having lesions greater than cervical intraepithelium neoplasm II (C1N2) reconfirmed by cervical biopsy. The potential controls (case: control=1∶2) were age matched (±2 yrs) and residency matched women who had had normal pap smears. In total, 100 cases (39 C1N2, 12 C1N3, 46 carcinoma in situ (CIS), and 3 invasive cancer) and 196 controls had the information on both questionnaire and data ofXRCC1 polymorphisms.

Results

The frequency ofArg/Arg, Arg/Gln, andGln/Gln in codon 399 among cases and controls was 54% (54/100), 38% (38/100), and 8% (8/100) and 58% (114/196), 37% (73/196), and 5% (9/196), respectively, which were not significantly different. No associations were also observed betweenXRCC1 codon 194 and 280 genotypes and cervical neoplasm. While dichotomized by age (<40 vs. ≥40 yrs), smoking status (active and passive smokers vs. non-smokers), and disease status (C1N2 and C1N3 vs. CIS and invasive cancer), the results remained insignificant.

Conclusions

The present findings suggest thatXRRC1 codon 194, 280 and 399 genotypes may not influence cervical neoplasm risk in the Taiwanese population.

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Authors and Affiliations

  1. Chia-Yi City Health Bureau, Chia-Yi, Taiwan

    Su-Chu Wu

  2. Graduate Institute of Occupational Safety and Health, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan

    Ming-Tsang Wu, Shu-Yi Chen, Trong-Neng Wu, Hsing-Yu Hwang, Chi-Kung Ho & Li-Hung Lee

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  1. Ming-Tsang Wu
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  2. Shu-Yi Chen
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  3. Trong-Neng Wu
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  4. Hsing-Yu Hwang
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Correspondence to Ming-Tsang Wu.

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Wu, MT., Chen, SY., Wu, TN. et al. No association between polymorphisms of the DNA repair geneXRCC1 and cervical neoplasm risk. Environ Health Prev Med 8, 100–103 (2003). https://doi.org/10.1007/BF02897923

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  • DOI: https://doi.org/10.1007/BF02897923

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