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Interleukin-1 and the response to injury

  • Cytokines
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Summary

Traumatic injury is the leading cause of morbidity and mortality in Americans less than 45 years old [26]. People surviving the initial insult undergo metabolic, hemodynamic and immunologic changes which contribute to both early and late complications. Though necessary for normal immunologic response and for wound healing, pathologic alterations of IL-1 synthesis, degradation, and binding to receptors on both a local and systemic level could lead to these changes. Manipulation of IL-1 mediated effects might be of therapeutic utility in the management of trauma in the future.

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Authors and Affiliations

  1. Department of Surgery, New England Medical Center, Boston, Mass., USA

    Elliot Kaplan

  2. Department of Medicine, New England Medical Center, Boston, Mass., USA

    Charles A. Dinarello & Jeffrey A. Gelfand

  3. Department of Geographic Medicine and Infectious Diseases, New England Medical Center, 750 Washington Street, 02111, Boston, MA, USA

    Jeffrey A. Gelfand

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  1. Elliot Kaplan
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  2. Charles A. Dinarello
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Kaplan, E., Dinarello, C.A. & Gelfand, J.A. Interleukin-1 and the response to injury. Immunol Res 8, 118–129 (1989). https://doi.org/10.1007/BF02919074

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