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Spontaneous regression of metastatic renal cell carcinoma following palliative irradiation of the primary tumour

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Abstract

A 58 years old man presented with a bulky renal primary tumour, paratracheallymphadenopathy and multiple pulmonary metastases. Spontaneous regression of intrathoracic metastases occurred after low dose palliative irradiation of the primary tumour. Serum levels of Interleukin-2 receptor were elevated during the period of tumour regression but concentrations of other cytokines were normal. Progressive abdominal disease eventually caused death. Autopsy confirmed the presence of renal cell carcinoma with intrathoracic metastases.

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References

  1. Everson, T. C., Cole, W. M. Spontaneous Regression of Cancer. Philadelphia: W.B. Saunders, 1966: 11–87.

    Google Scholar 

  2. Bloom, H. J. G. Hormone induced and spontaneous regression of metastatic cancer. Cancer 1983: 32, 1066–1071.

    Article  Google Scholar 

  3. Montie, J. E., Stewart, B. H., Straffon, R. A. et al. The role of adjunctive nephrectomy in patients with metastatic renal cell carcinoma. J. Urol. 1977: 117, 272–275.

    PubMed  CAS  Google Scholar 

  4. Muss, H. B. Renal cell carcinoma. In: DeVita, V. T., Hellman, S., Rosenberg, S. A. eds. Biologic therapy of cancer. Philadelphia: J. B. Lippincott Co., 1991: 298–311.

    Google Scholar 

  5. West, W. H. Continuous infusion recombinant interleukin2 (rIL-2) in adoptive cellular therapy of renal carcinoma and other malignancies. Cancer Treatment Reviews 1989: 16 (suppl. A), 83–89.

    Article  PubMed  Google Scholar 

  6. Neidhart, J. A. Interferon therapy for the treatment of renal cancer. Cancer 1986: 57, 1696–1699.

    Article  PubMed  CAS  Google Scholar 

  7. Atzpodien, J., Korfer, A., Franks, C. et al. Home therapy with recombinant interleukin-2 and interferon alpha2b in advanced human malignancies. Lancet 1990: 335, 1509–1512.

    Article  PubMed  CAS  Google Scholar 

  8. Fairlamb, D. J. Spontaneous regression of metastases of renal cancer. A report of two cases including the first recorded regression following irradiation of a dominant metastasis and review of the world literature. Cancer 1981: 47, 2101–2106.

    Article  Google Scholar 

  9. Kjaer, M. The role of medroxyprogesterone acetate (MPA) in the treatment of advanced renal adenocarcinoma. Cancer Treatment Reviews 1988: 15, 195–209.

    Article  PubMed  CAS  Google Scholar 

  10. Marcus, S. G., Choyke, P. L., Reiter, R. et al. Regression of metastatic renal cell carcinoma after cytoreductive nephrectomy. J. Urol. 1993: 150, 463–6.

    PubMed  CAS  Google Scholar 

  11. Pansera, F. Regression in renal cell carcinoma as re-expression of cell death in kidney development. Perspectives in Biology & Medicine 1992: 426–21.

  12. Creaven, P. J., Brenner, D. E., Cowens, J. W. et al. A Phase I clinical trial of recombinant tumor necrosis factor given daily for five days. Cancer Chemother. Pharmacol. 1989: 23, 186–191.

    PubMed  CAS  Google Scholar 

  13. Bartsh, H. H., Pfizenmaier, K., Schroeder, M. et al. Intralesional application of human tumour necrosis factor alpha induces local tumor regression in patients with advanced malignancies. Eur. J. Cancer Clin. Oncol. 1989: 25, 287–291.

    Article  Google Scholar 

  14. Goustin, A. S., Leof, E. B., Shipley, G. D. et al. Growth factors and cancer. Cancer Res. 1986: 46, 1015–1029.

    PubMed  CAS  Google Scholar 

  15. Socher, S. H., Martinez, D., Craig, J. B. et al. Tumor Necrosis Factor not detectable in patients with clinical cancer cachexia. J. Natl. Cancer Inst. 1988: 80, 595–598.

    Article  PubMed  CAS  Google Scholar 

  16. Cotran, R. S., Kumar, V., Robbins, S. I. Robbins. Pathologic Basis of Disease, 4th ed. Philadelphia: W. B. Saunders; 1989: 686.

    Google Scholar 

  17. Lissoni, P., Rescaldani, R., Rovelli, F. et al. Serum levels of soluble interleukin-2 receptors and their relation to lymphocyte subpopulations in patients with metastatic solid tumours. Brit. J. Cancer 1989; 60: 616–617.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Northern Ireland Centre for Clinical Oncology, Belvoir Park Hospital, Hospital Road, BT8 8JR, Belfast, Northern Ireland

    M. P. MacManus, R. J. Harte & S. Stranex

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  1. M. P. MacManus
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  2. R. J. Harte
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  3. S. Stranex
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MacManus, M.P., Harte, R.J. & Stranex, S. Spontaneous regression of metastatic renal cell carcinoma following palliative irradiation of the primary tumour. I.J.M.S. 163, 461–463 (1994). https://doi.org/10.1007/BF02940567

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  • DOI: https://doi.org/10.1007/BF02940567

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