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The hypodipsia-hypernatraemia syndrome presenting with obesity

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Summary

Following a suspected viral infection 4 years previously, a 9-year-old boy developed obesity, hypodipsia, hypernatraemia, hyperosmolality and hyperprolactinaemia. The renal handling of solute and water was normal, but there was a decreased sensitivity of hypothalamic osmoreceptors to both hypernatraemia and water loading. Therapeutic trials with a thiazide diuretic, an aldosterone antagonist, bromocriptine, and longterm sodium restriction with high fluid intake failed to maintain serum sodium and plasma osmolality within the normal range.

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References

  • Blank, M. S. and Farnsworth, P. B. 1974. Idiopathic symptomatic hypernatremia in a 9-year-old boy. A clinical and physiological evaluation. J. Pediatr. 85, 215–219.

    Article  PubMed  CAS  Google Scholar 

  • Goldberg, M., Weinstein, G., Adesman, J. and Bleicher, S. J. 1967. Asymptomatic hypovolemic hypernatremia. A variant of essential hypernatremia. Am. J. Med. 43, 804–810.

    Article  PubMed  CAS  Google Scholar 

  • Hayek, A., Bryant, P. D. and Woodside, W. F. 1983. Hypernatraemia induces hyperlipaemia and a fatty liver. Metabolism 32, 1–3.

    Article  PubMed  CAS  Google Scholar 

  • Maddy, J. A. and Winternitz, W. W. 1971. Hypothalamic syndrome with hypernatraemia and muscular paralysis. Am. J. Med. 51, 394–402.

    Article  PubMed  CAS  Google Scholar 

  • Shaad, U., Vassella, F., Zuppinger, K. and Oetliker, O. 1979. Hypodipsia-hyponatremia syndrome. Helv. Paediat. Acta 34, 63–76.

    Google Scholar 

  • Stevenson, J. A. F., Welt, L. G. and Orloff, J. 1950. Abnormalities of water and electrolyte metabolism in rats with hypothalamic lesions. Am. J. Physiol. 161, 35–39.

    PubMed  CAS  Google Scholar 

  • Travis, L. B., Dodge, W. F., Waggener, J. D. and Kashemsant, C. 1967. Defective thirst mechanism secondary to a hypothalamic lesion: Studies in a child with adipsia, polyphagia, obesity, and persistent hyperosmolality. J. Pediat. 70, 915–926.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Endocrine Unit, Mater Misericordiae Hospital, Dublin

    David Powell, Mary Codd & Petr Skrabanek

  2. Our Lady's Hospital for Sick Children, Dublin

    Edward Tempany

Authors
  1. David Powell
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  2. Mary Codd
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  3. Petr Skrabanek
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  4. Edward Tempany
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Powell, D., Codd, M., Skrabanek, P. et al. The hypodipsia-hypernatraemia syndrome presenting with obesity. I.J.M.S. 152, 357–359 (1983). https://doi.org/10.1007/BF02954735

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  • DOI: https://doi.org/10.1007/BF02954735

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