Abstract
Overproduction of prostaglandins has been considered in mediation of inflammation and carcinogenic process. On this line, the inhibitors of prostaglandin biosynthetic enzyme cyclooxygenase (COX) have played a role of anti-inflammatory and cancer chemopreventive agents. In our continuous efforts to search anti-inflammatory and chemopreventive agents from natural products, bioassay-guided fractionation led to the isolation of curdione from the rhizome ofCurcuma zedoaria with the inhibitory effect on the production of prostaglandin E2 in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells in a concentration-dependent manner (IC50 = 1.1 μM). Mechanistic studies suggest that the suppression of cyclooxygenase-2 (COX-2) mRNA expression is, at least in part, involved in this inhibitory activity of curdione.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bandaru, S. R., Chinthalapally, Y R., and Karen, S., Evaluation of C0X-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.Cancer Res., 56, 4566- 4569(1996).
Harimaya, K., Gao, J. F, Ohkura, T., Kawamata, T., Iitaka, Y, Guo, Y. T., and Inayama, S., A series of sesquiterpenes with a 7α-isopropyl side chain and related compounds isolated fromCurcuma wenyujin.Chem. Pharm. Bull., 39, 843–853 (1991).
Hong, C. H., Noh, M. S., Lee, W. Y, and Lee, S. K., Inhibitory effects of natural sesquiterpenoids isolated from the rhizomes ofCurcuma zedoaria on prostaglandin E2 and nitric oxide production.Planta Med., 68, 545–547 (2002).
Kim, S. S., Oh, O. J., Min, H. Y, Park, E. J., Kim, Y, Park, H. J., Han, Y N., and Lee, S. K., Eugenol suppresses cyclo- oxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells.Life Sci., 73, 337–348 (2003).
Masferver, J. L, Zweifei, B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G, Isakson, P. C, and Seibert, K., Selective inhibition of cyclooxygenase-2in vivo is antiinflammatory and nonulcerogenic.Proc. Natl. Acad. Sci. U.S.A., 91, 3228–3232 (1994).
Matsuda, H., Ninomiya, K., Morikawa, T., and Yoshikawa, M., Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae rhizoma on D-galactosamine / lipopoly- saccharide-induced liver injury.Bioorg. Med. Chem. Lett., 8, 339–344(1998).
Simon, L. S., Role of regulation of cyclooxygenase-2 during inflammation.Am. J. Med., 106, 37S-42S (1999).
Subbaramaiah, K., Telang, N., Ramonetti, J. T, Araki, R., Devito, B., Weksker, B. B., and Dannenberg, A. J., Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells.Cancer Res., 56, 4424–4429 (1996).
Toshihiko, K., Ronald, L, Vernon, E. S., Gray, J. K, Robert, B. K, Chinthalapally, V. R., and Bandaru, S. R., Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stage of colon cancer.Cancer Res., 59, 597–601 (1999).
Yoshioka, T., Fujii, E., Endo, M., Wada, K., Tokunaga, Y., Shiba, N., Hohsho, H., Shibuya, H., and Muraki, T., Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene.Inflamm. Res., 47, 476–481 (1998).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Oh, OJ., Min, HY. & Lee, S.K. Inhibition of inducible prostaglandin E2 production and cyclooxy-genase-2 expression by curdione fromCurcuma zedoaria . Arch. Pharm. Res. 30, 1236–1239 (2007). https://doi.org/10.1007/BF02980264
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02980264