Abstract
Three TNFα-inhibitory lignans were isolated from the flower buds ofMagnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-α production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50=51 µM).
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Chae, SH., Kim, PS., Cho, JY. et al. Isolation and identification of inhibitory compounds on TNF-α production fromMagnolia fargesii . Arch. Pharm. Res. 21, 67–69 (1998). https://doi.org/10.1007/BF03216755
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DOI: https://doi.org/10.1007/BF03216755