Abstract
Red variants of S. Japonicas show unique ecological characteristics and are indigenous to Jeju Island in South Korea. Various biological activities of red sea cucumber extracts (RSCEs) were evaluated. In comparison with positive controls, anti-oxidant activity of RSCEs was very low. In HL-60 and HT-29 cells, chloroform and ethyl acetate (EtOAc) fractions showed higher than 80 and 60% growth inhibition, respectively. Nuclear condensation and increased pro-apoptotic signaling revealed that RSCEs triggered apoptosis. EtOAc fractions also showed strong anti-inflammatory effects at sub-lethal concentrations in lipolysaccharide-stimulated RAW264.7 cells and suppressed more than 90% of nitric oxide (NO) and prostaglandin 2 productions at 50 μg/mL by inhibiting inducible NO synthase and cydooxygenase-2. Water-soluble fractions showed good antibacterial effects against Staphylococcus aureus and Staphylococcus epidermidis.
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Park, SY., Lim, H.K., Lee, S. et al. Biological effects of various solvent fractions derived from Jeju Island red sea cucumber (Stichopus japonicas). J Korean Soc Appl Biol Chem 54, 718–724 (2011). https://doi.org/10.1007/BF03253150
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DOI: https://doi.org/10.1007/BF03253150