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Absorption of paracetamol from suppositories in geriatric patients with fecal accumulation in the rectum

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Abstract

The bioavailability of paracetamol from suppositories was studied in 16 geriatric in-patients in stable clinical condition; 9 had significant amounts of feces in the rectum. Rectal accumulation of feces reduced the peak plasma paracetamol concentration by 32% (p = 0.05) and the AUC0−8h by 27% (p = 0.04). The peak concentration, however, appeared earlier among patients with rectal accumulation of feces. Compared to findings in 6 healthy young controls, geriatric patients had higher plasma concentrations of the main paracetamol metabolites. (Aging 3: 25-29,1991)

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Authors and Affiliations

  1. University Department of Geriatric Medicine, Ullevaal Hospital, 0407, Oslo 4, Norway

    I. J. Hagen &  K. Laake

  2. B. Pharm, Apothekernes Laboratorium Inc., Oslo, Norway

    E. M. Haram

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  1. I. J. Hagen
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  2. E. M. Haram
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  3. K. Laake
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Hagen, I.J., Haram, E.M. & Laake, K. Absorption of paracetamol from suppositories in geriatric patients with fecal accumulation in the rectum. Aging Clin Exp Res 3, 25–29 (1991). https://doi.org/10.1007/BF03323971

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  • DOI: https://doi.org/10.1007/BF03323971

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