Abstract
Colonies of fibroblasts are formed in monolayer cultures of bone marrow, spleen, and thymus cells of adult mice with an efficiency of colony formation (per 105 cells) of 2.2 for bone marrow, 0.20 for spleen, and 0.16 for thymus. On irradiation of mice with a dose of 150 R, about half of the fibroblasts colony-forming units in the bone marrow die; during the next 6 days their number falls a further fivefold, with a return to the normal level 25 days after irradiation.
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Gorskaya, Y.F., Fridenshtein, A.Y. & Kulagina, N.N. Precursor cells of fibroblasts detected by in vitro cloning of cells from hematopoietic organs of normal and irradiated mice. Bull Exp Biol Med 81, 765–768 (1976). https://doi.org/10.1007/BF00797159
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DOI: https://doi.org/10.1007/BF00797159