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Macrophage colon-stimulating factor (M-CSF) is essential for differentiation rather than proliferation of osteoclast progenitors

  • Session VI: Pathogenesis: Cytokines And Immunity
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References

  1. Udagawa N, Takahashi N, Akatsu T, et al. Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci USA 1991;87:7260–4.

    Google Scholar 

  2. Stanley ER, Heard PM. Factors regulating macrophage production and growth: purification and some properties of the colony-stimulating factor from medium conditioned by mouse L cells. J Biol Chem 1977;252:4305–12.

    Google Scholar 

  3. Marks SC Jr. Osteoclast biology: lessons from mammalian mutations. Am J Med Genet 1989;34:4305–12.

    Google Scholar 

  4. Yoshida H, Hayashi S, Kunisada T, et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990;345:442–4.

    Google Scholar 

  5. Felix R, Cecchini MG, Fleisch H. Macrophage colony stimulating factor restores in vivo bone resorption in theop/op osteopetrotic mouse. Endocrinology 1990;127:2592–4.

    Google Scholar 

  6. Kodama H, Yamasaki A, Nose M, et al. Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor. J Exp Med 1991;173:239–72.

    Google Scholar 

  7. Takahashi N, Yamana H, Yoshiki S, et al. Osteoclast-like cell formation and its regulation by osteopetrotic hormones in mouse bone marrow cultures. Endocrinology 1988;122:1373–82.

    Google Scholar 

  8. Takahashi N, Udagawa N, Akatsu T, et al. Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells. Endocrinology 1991;128:1792–6.

    Google Scholar 

  9. Kodama H, Nose M, Niida S, Yamasaki A. Essential role of macrophage colony-stimulating factor in osteoclast differentiation supported by stromal cells. J Exp Med 1991;173:1291–4.

    Google Scholar 

  10. Takahashi N, Udagawa N, Akatsu T, et al. Role of colony-stimulating factors in osteoclast development. J Bone Miner Res 1991;6:977–85.

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan

    T. Suda, S. Tanaka & N. Takahashi

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  1. T. Suda
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  2. S. Tanaka
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  3. N. Takahashi
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Suda, T., Tanaka, S. & Takahashi, N. Macrophage colon-stimulating factor (M-CSF) is essential for differentiation rather than proliferation of osteoclast progenitors. Osteoporosis Int 3 (Suppl 1), 111–113 (1993). https://doi.org/10.1007/BF01621881

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