Abstract
Forty patients with multifocal and multicentric cerebral tumours were retrospectively studied. The patients were divided into two groups: ten patients with multicentric tumours (group A), and 30 patients with multifocal tumours. As far as their preoperative clinical history and the incidence of the various symptoms and signs are concerned, there were no significant differences between the two groups. CT permitted a correct diagnosis in 90% of the cases. All of the patients underwent the removal of the tumour(s) and received radiotherapy; 30 patients also received chemotherapy. In group A, nine patients died and one was lost to follow-up one year after treatment; the average survival was ten months from the appearance of the multicentric tumour. In group B, 29 patients died and one is still alive two years after treatment; the average survival was six months. We consider the problems of diagnosis and the long-term follow-up of patients.
Sommario
Gli autori riportano uno studio retrospettivo su 40 pazienti affetti da tumori cerebrali multifocali e multicentrici del sistema nervoso centrale. I pazienti sono stati suddivisi in due gruppi: 1) gruppo A formato da 10 pazienti con tumore multicentrico; 2) gruppo B formato da 30 pazienti con tumore multifocale. Non si sono osservate significative differenze fra i due gruppi per quanto riguarda la durata della storia e l'incidenza dei sintomi e dei segni neurologici. La TC ha permesso una corretta diagnosi nel 90% dei casi. Tutti i pazienti sono stati sottoposti ad intervento chirurgico ed a radioterapia e 30 anche a chemioterapia. Nel gruppo A, 9 pazienti sono deceduti ed uno è stato perso al follow-up un anno dopo il trattamento. La sopravvivenza media è stata di 10 mesi dalla comparsa del tumore. Nel gruppo B, 29 pazienti sono deceduti ed uno è vivente due anni dopo il trattamento. La sopravvivenza media à stata di 6 mesi. Abbiamo trattato i problemi diagnostici e prognostici di questa patologia.
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Salvati, M., Cervoni, L., Celli, P. et al. Multicentric and multifocal primary cerebral tumours. Methods of diagnosis and treatment. Ital J Neuro Sci 18, 17–20 (1997). https://doi.org/10.1007/BF02106225
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DOI: https://doi.org/10.1007/BF02106225