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Serum type IV collagen in various liver diseases in comparison with serum 7S collagen, laminin, and type III procollagen peptide

  • Liver, Pancreas and Biliary Tract
  • Published:
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Abstract

The clinical significance of the immunoreactive triple helical domain of type IV collagen in serum was evaluated in 73 healthy controls and 161 patients with various biopsy-proven liver diseases. Although serum levels of type III procollagen peptide were increased in all liver diseases, those of type IV collagen, 7S collagen, and laminin were principally increased in chronic liver diseases associated with hepatic fibrogenesis/fibrosis. In both non-alcoholic and alcoholic liver diseases, 7S collagen was increased in serum, while type IV collagen and laminin in serum were particularly increased in alcoholic liver diseases and in hepatocellular carcinoma, in which latter the sensitivity was greater for type IV collagen than for laminin. Gel filtration analysis in Sephacryl S-400 revealed type IV collagen in serum to be a single molecular form with a molecular weight that correspond to type IV collagen, whereas 7S collagen was recognized as several heterogeneous macromolecules. These findings indicate that serum type IV collagen is derived from the type IV protocollagen pool, and is a sensitive marker for the fibrogenetic process in hepatic basement membranes.

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Authors and Affiliations

  1. Saiseikai Gotsu General Hospital, 1551 Gotsu-cho, 695, Gotsu-shi, Shimane, Japan

    Chisato Hirayama

  2. Yamanashi Medical College, Yamanachi, Japan

    Hiroshi Suzuki

  3. Department of Internal Medicine, Kanazawa Medical University, Kanazawa, Japan

    Akira Takada

  4. Japan Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan

    Kiyoshi Fujisawa

  5. Second Department of Internal Medicine, School of Medicine, Kurume University, Kurume, Japan

    Kyuichi Tanikawa

  6. Department of Internal Medicine, Tokyo Senbai Hospital, Tokyo, Japan

    Shogo Igarashi

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  1. Chisato Hirayama
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  2. Hiroshi Suzuki
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  3. Akira Takada
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  4. Kiyoshi Fujisawa
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  5. Kyuichi Tanikawa
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  6. Shogo Igarashi
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Hirayama, C., Suzuki, H., Takada, A. et al. Serum type IV collagen in various liver diseases in comparison with serum 7S collagen, laminin, and type III procollagen peptide. J Gastroenterol 31, 242–248 (1996). https://doi.org/10.1007/BF02389524

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  • DOI: https://doi.org/10.1007/BF02389524

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