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Islet Transplantation: Factors in Short-Term Islet Survival

  • Review
  • Published:
Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Islet transplantation has the potential to cure type 1 diabetes. In recent years, the proportion of patients achieving initial insulin independence has improved, but longer term outcomes remain poor compared to those for whole pancreas transplants. This review article will discuss factors affecting islet yield and viability leading up to transplantation and in the immediate post-transplant period.

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Abbreviations

ADSC:

Adipose derived stem cells

IBMIR:

Instant blood-mediated inflammatory reaction

MSC:

Mesenchymal stem cells

SC:

Sertoli cells

T1D:

Type 1 diabetes

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  1. Diabetes and Transcription Factors, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW, 2010, Australia

    Natasha A. Deters, Rebecca A. Stokes & Jenny E. Gunton

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  1. Natasha A. Deters
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  2. Rebecca A. Stokes
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  3. Jenny E. Gunton
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Correspondence to Jenny E. Gunton.

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Deters, N.A., Stokes, R.A. & Gunton, J.E. Islet Transplantation: Factors in Short-Term Islet Survival. Arch. Immunol. Ther. Exp. 59, 421–429 (2011). https://doi.org/10.1007/s00005-011-0143-0

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