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Roles of Myeloid-Derived Suppressor Cells in Cancer Metastasis: Immunosuppression and Beyond

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Metastasis is the direst face of cancer, and it is not a feature solely dependent on cancer cells; however, a complex interaction between cancer cells and host causes this process. Investigating the mechanisms of metastasis can lead to its control. Myeloid-derived suppressor cells (MDSCs) are key components of tumor microenvironment that favor cancer progression. These cells result from altered myelopoiesis in response to the presence of tumor. The most recognized function of MDSCs is suppressing anti-tumor immune responses. Strikingly, these cells are among important players in cancer dissemination and metastasis. They can exert their effect on metastatic process by affecting anti-cancer immunity, epithelial–mesenchymal transition, cancer stem cell formation, angiogenesis, establishing premetastatic niche, and supporting cancer cell survival and growth in metastatic sites. In this article, we review and discuss the mechanisms by which MDSCs contribute to cancer metastasis.

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Acknowledgements

We would like to thank Dr. Susanna Mandruzzato from Oncology and Immunology Section, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy, for evaluation of the manuscript and her expert comments to improve the paper.

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Authors and Affiliations

  1. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Amin Pastaki Khoshbin, Mahsa Eskian & Mahsa Keshavarz-Fathi

  2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Amin Pastaki Khoshbin & Mahsa Keshavarz-Fathi

  3. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Dr Qarib St, Keshavarz Blvd, Tehran, 14194, Iran

    Mahsa Eskian, Mahsa Keshavarz-Fathi & Nima Rezaei

  4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Mahsa Eskian & Nima Rezaei

  5. Breast Cancer Association (BrCA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Mahsa Keshavarz-Fathi

  6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  7. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Sheffield, UK

    Nima Rezaei

Authors
  1. Amin Pastaki Khoshbin
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  2. Mahsa Eskian
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  3. Mahsa Keshavarz-Fathi
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  4. Nima Rezaei
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Corresponding author

Correspondence to Nima Rezaei.

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The authors declare they had no conflicts of interest.

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Pastaki Khoshbin, A., Eskian, M., Keshavarz-Fathi, M. et al. Roles of Myeloid-Derived Suppressor Cells in Cancer Metastasis: Immunosuppression and Beyond. Arch. Immunol. Ther. Exp. 67, 89–102 (2019). https://doi.org/10.1007/s00005-018-0531-9

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  • DOI: https://doi.org/10.1007/s00005-018-0531-9

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