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Oncogenic protein tyrosine kinases

Dysfunction of the RET receptor in human cancer

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Abstract.

RET is the receptor for glial-derived neurotrophic factor growth factors. It is a paradigm of a single gene that causes different types of human cancer when targeted by different genetic alterations. Like other receptor tyrosine kinases, once activated, RET recruits a variety of signaling molecules that mediate biological responses. Here we review data on the signaling pathways that lead to RET-mediated cell transformation and recent evidence that manipulation of RET holds promise for thyroid cancer treatment.

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Authors and Affiliations

  1. Dipartimento di Biologia e Patologia Cellulare e Molecolare, University ‘Federico II’, via S. Pansini 5, 80131, Naples, Italy

    M. Santoro, F. Carlomagno, R. M. Melillo & A. Fusco

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  1. M. Santoro
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  2. F. Carlomagno
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  3. R. M. Melillo
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  4. A. Fusco
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Correspondence to M. Santoro.

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Santoro, M., Carlomagno, F., Melillo, R.M. et al. Oncogenic protein tyrosine kinases. CMLS, Cell. Mol. Life Sci. 61, 2954–2964 (2004). https://doi.org/10.1007/s00018-004-4276-8

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  • DOI: https://doi.org/10.1007/s00018-004-4276-8

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