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Inhibitor of growth tumor suppressors in cancer progression

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Abstract

The inhibitor of growth (ING) family of tumor suppressors has five members and is implicated in the control of apoptosis, senescence, DNA repair, and cancer progression. However, little is known about ING activity in the regulation of cancer progression. ING members and splice variants seem to behave differently with respect to cancer invasion and metastasis. Interaction with histone trimethylated at lysine 4 (H3K4me3), hypoxia inducible factor-1 (HIF-1), p53, and nuclear factor kappa-B (NF-κB) are potential mechanisms by which ING members exert effects on invasion and metastasis. Subcellular mislocalization, rapid protein degradation, and to a lesser extent ING gene mutation are among the mechanisms responsible for inappropriate ING levels in cancer cells. The aim of this review is to summarize the different roles of ING family tumor suppressors in cancer progression and the molecular mechanisms involved.

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Acknowledgments

This work was supported by Canadian Institutes of Health Research (MOP-84559 and MOP-93810) and Canadian Dermatology Foundation to G. Li. B. Piche is a recipient of the trainee award from CIHR Skin Research Training Centre.

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  1. Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 2660 Oak Street, Vancouver, BC, V6H 3Z6, Canada

    Brad Piche & Gang Li

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Piche, B., Li, G. Inhibitor of growth tumor suppressors in cancer progression. Cell. Mol. Life Sci. 67, 1987–1999 (2010). https://doi.org/10.1007/s00018-010-0312-z

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  • DOI: https://doi.org/10.1007/s00018-010-0312-z

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