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Thyroid hormone actions in liver cancer

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Abstract

The thyroid hormone 3,3′,5-triiodo-l-thyronine (T3) mediates several physiological processes, including embryonic development, cellular differentiation, metabolism, and the regulation of cell proliferation. Thyroid hormone receptors (TRs) generally act as heterodimers with the retinoid X receptor (RXR) to regulate target genes. In addition to their developmental and metabolic functions, TRs have been shown to play a tumor suppressor role, suggesting that their aberrant expression can lead to tumor transformation. Conversely, recent reports have shown an association between overexpression of wild-type TRs and tumor metastasis. Signaling crosstalk between T3/TR and other pathways or specific TR coregulators appear to affect tumor development. Since TR actions are complex as well as cell context-, tissue- and time-specific, aberrant expression of the various TR isoforms has different effects during diverse tumorigenesis. Therefore, elucidation of the T3/TR signaling mechanisms in cancers should facilitate the identification of novel therapeutic targets. This review provides a summary of recent studies focusing on the role of TRs in hepatocellular carcinomas (HCCs).

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Acknowledgments

This work was supported by grants from Chang-Gung University, Taoyuan, Taiwan (CMRPD 34013, NMRP 140511) and National Science Council of the Republic of China (NSC 94-2320-B-182-052).

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  1. Department of Biochemistry, College of Medicine, Chang-Gung University, 259 Wen-hwa 1 Road, Taoyuan, 333, Taiwan

    Sheng-Ming Wu, Wan-Li Cheng & Kwang-Huei Lin

  2. Pre-med Program, Pacific Union College, Angwin, CA, 94508, USA

    Crystal D. Lin

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Wu, SM., Cheng, WL., Lin, C.D. et al. Thyroid hormone actions in liver cancer. Cell. Mol. Life Sci. 70, 1915–1936 (2013). https://doi.org/10.1007/s00018-012-1146-7

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  • DOI: https://doi.org/10.1007/s00018-012-1146-7

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