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Life in the Fas lane: differential outcomes of Fas signaling

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Abstract

Fas, also known as CD95 or APO-1, is a member of the tumor necrosis factor/nerve growth factor superfamily. Although best characterized in terms of its apoptotic function, recent studies have identified several other cellular responses emanating from Fas. These responses include migration, invasion, inflammation, and proliferation. In this review, we focus on the diverse cellular outcomes of Fas signaling and the molecular switches identified to date that regulate its pro- and anti-apoptotic functions. Such switches occur at different levels of signal transduction, ranging from the receptor through to cross-talk with other signaling pathways. Factors identified to date including other extracellular signals, proteins recruited to the death-inducing signaling complex, and the availability of different intracellular components of signal transduction pathways. The success of therapeutically targeting Fas will require a better understanding of these pathways, as well as the regulatory mechanisms that determine cellular outcome following receptor activation.

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Acknowledgments

The authors would like to acknowledge funding from Science Foundation Ireland.

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  1. Department of Pathology, University College Cork, National University of Ireland, Cork, Ireland

    Elizabeth Brint

  2. Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland

    Grace O’Callaghan & Aileen Houston

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  1. Elizabeth Brint
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Correspondence to Aileen Houston.

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Brint, E., O’Callaghan, G. & Houston, A. Life in the Fas lane: differential outcomes of Fas signaling. Cell. Mol. Life Sci. 70, 4085–4099 (2013). https://doi.org/10.1007/s00018-013-1327-z

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