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Cytotoxic lipid esters from Peucedanum ledebourielloides

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Abstract

Two cancer cell growth inhibitory esters, 1,2-dipalmitoyl-3-glucosyl glycerol (1) and 1,6-dihydroxy-hexane-bis-palmitoyl ester (2), together with arachidic acid-2-hydroxy-glycerol ester, daucosterol, and oleanolic acid, were isolated from the roots of Peucedanum ledebourielloides (Apiaceae family). The structures were determined by spectroscopic analyses. The esters 1 and 2 displayed significant activity against the SGC-7901, HT-29, and HL-60 cancer cell lines.

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Acknowledgement

The authors thank the Department of Education of Hunan (07B065) and the Department Science and Technology of Hunan (2007FJ4155) for financial support. Special thanks are due to the Analytical Center, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany of Chinese Academy of Sciences, for recording IR, MS, and NMR spectra. The authors also thank Prof. Langran Xu for plant identification. Two authors (GRP and JD) are pleased to acknowledge the financial support of CA90441-5 and CA90441-06A1 awarded by the Division of Cancer Treatment and Diagnosis, National Cancer Institute, DHHS, the Arizona Biomedical Research Commission, and the assistance of Professor Fiona Hogan.

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Authors and Affiliations

  1. Institute of Pharmacy and Pharmacology, Nanhua University, Hengyang, 421001, People’s Republic of China

    Xing Zheng & Duanfang Liao

  2. Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, 85287, USA

    Xing Zheng & George R. Pettit

  3. Department of Chemistry, Colorado State University, Fort Collins, CO, 80526, USA

    Jiang Du

  4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, People’s Republic of China

    Yunlong Xu

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  1. Xing Zheng
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  2. Jiang Du
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  3. Yunlong Xu
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  4. Duanfang Liao
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  5. George R. Pettit
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Correspondence to Xing Zheng.

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Zheng, X., Du, J., Xu, Y. et al. Cytotoxic lipid esters from Peucedanum ledebourielloides . Med Chem Res 19, 337–343 (2010). https://doi.org/10.1007/s00044-009-9193-9

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  • DOI: https://doi.org/10.1007/s00044-009-9193-9

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