Abstract
Background
A joint analysis of clinical data from centres within the European section of the International Society of Intraoperative Radiation Therapy (ISIORT-Europe) was undertaken in order to define the range of intraoperative radiotherapy (IORT) techniques and indications encompassed by its member institutions.
Materials and methods
In 2007, the ISIORT-Europe centres were invited to record demographic, clinical and technical data relating to their IORT procedures in a joint online database. Retrospective data entry was possible.
Results
The survey encompassed 21 centres and data from 3754 IORT procedures performed between 1992 and 2011. The average annual number of patients treated per institution was 42, with three centres treating more than 100 patients per year. The most frequent tumour was breast cancer with 2395 cases (63.8 %), followed by rectal cancer (598 cases, 15.9 %), sarcoma (221 cases, 5.9 %), prostate cancer (108 cases, 2.9 %) and pancreatic cancer (80 cases, 2.1 %). Clinical details and IORT technical data from these five tumour types are reported.
Conclusion
This is the first report on a large cohort of patients treated with IORT in Europe. It gives a picture of patient selection methods and treatment modalities, with emphasis on the main tumour types that are typically treated by this technique and may benefit from it.
Zusammenfassung
Hintergrund
Die europäische Gruppe der Internationalen Gesellschaft für Intraoperative Radiotherapie (ISIORT-Europe) hat eine gemeinsame Analyse von technischen und klinischen Daten unternommen, um die Bandbreite der intraoperativen Techniken und Indikationen innerhalb ihrer Mitgliederinstitutionen zu erfassen.
Material und Methode
Im Jahr 2007 wurden die Mitgliederzentren eingeladen, demographische, klinische, dosimetrische und technische Details ihrer IORT-Verfahren in der gemeinsamen Registerdatenbank (http://www.isiort.org/htm/isiort_europe.htm) einzupflegen, wobei eine retrospektive Eingabe zulässig war.
Ergebnisse
An der Studie nahmen 21 Zentren teil, wobei pro Zentrum im Jahresdurchschnitt 42 Patienten behandelt wurden und 3 Institutionen über 100 Patienten pro Jahr therapierten. Insgesamt wurden im Zeitraum zwischen 1992 und 2011 Daten zu 3754 IORT-Verfahren erfasst. Die häufigste Tumorentität bildete das Mammakarzinom mit 2395 Fällen (63,8 %), gefolgt von Rektumkarzinomen mit 598 Fällen (15,9 %), 221 Sarkomen (5,9 %), 108 Prostatakarzinomen (2,9 %) sowie 80 Pankreaskarzinomen (2,1 %). Zu diesen 5 Tumorarten werden klinische Angaben und technische Details der IORT berichtet.
Schlussfolgerung
Erstmals wurden anhand einer großen Patientenzahl Selektionen und Modalitäten zur intraoperativen Radiotherapie in Europa erfasst, mit dem Schwerpunkt auf die hauptsächlich mittels IORT behandelten Tumorentitäten, die von dieser Therapie profitieren könnten.
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Acknowledgments
This project was supported in part by a research grant from Instituto Carlos III, Spanish Ministry of Science and Innovation
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On behalf of all authors, the corresponding author states that there are no conflicts of interest.
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Data from this work were presented at the ESTRO Anniversary Conference, London, UK, 8–12 May 2011 and at the ISIORT Meeting, Baveno, Italy, June 22–24, 2012.
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Krengli, M., Calvo, F., Sedlmayer, F. et al. Clinical and technical characteristics of intraoperative radiotherapy. Strahlenther Onkol 189, 729–737 (2013). https://doi.org/10.1007/s00066-013-0395-1
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DOI: https://doi.org/10.1007/s00066-013-0395-1