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The role of intramedullary nailing in treatment of open fractures

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Abstract

The management of open fractures remains one of the greatest challenges to orthopedic trauma surgeons. Damage to the soft tissue envelope together with periosteal stripping are the most important factors making open fractures prone to complications such as nonunion and infection. Urgent and thorough soft tissue debridement, proper surgical fracture stabilization as well as the administration of intravenous and local antibiotics as adjunctive therapy are mandatory to reduce the risk of infection. Intramedullary nail osteosynthesis has become an accepted treatment method of open long bone fractures. Especially at sites of sparse soft tissue coverage like the proximal and distal tibia, early intramedullary stabilization proved advantageous for its superior biomechanical stability, the chance of early soft tissue reconstruction, shorter healing times, and quicker rehabilitation. However, due to a potential risk of deep infection, especially when a reamed technique is applied, nailing of open fractures remains contentious. In this review, we focus on the current evidence of nail osteosynthesis in open fractures and delineate its value with respect to other possible treatment options.

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References

  1. Rajasekaran S. Ganga hospital open injury severity score—a score to prognosticate limb salvage and outcome measures in Type IIIb open tibial fractures. Indian J Orthop. 2005;39:4–13.

    Google Scholar 

  2. Rajasekaran S. Early versus delayed closure of open fractures. Injury. 2007;38:890–5.

    Article  CAS  PubMed  Google Scholar 

  3. Rajasekaran S, Naresh Babu J, Dheenadhayalan J, Shetty AP, Sundararajan SR, Kumar M, et al. A score for predicting salvage and outcome in Gustilo type-IIIA and type-IIIB open tibial fractures. J Bone Jt Surg Br. 2006;88:1351–60.

    Article  CAS  Google Scholar 

  4. Velazco A, Fleming LL. Open fractures of the tibia treated by the Hoffmann external fixator. Clin Orthop Relat Res. 1983;180:125–32.

    PubMed  Google Scholar 

  5. Khatod M, Botte MJ, Hoyt DB, Meyer RS, Smith JM, Akeson WH. Outcomes in open tibia fractures: relationship between delay in treatment and infection. J Trauma. 2003;55:949–54.

    Article  PubMed  Google Scholar 

  6. Okike K, Bhattacharyya T. Trends in the management of open fractures. A critical analysis. J Bone Jt Surg Am. 2006;88:2739–48.

    Article  Google Scholar 

  7. Sirkin M, Sanders R, DiPasquale T, Herscovici D. A staged protocol for soft tissue management in the treatment of complex pilon fractures. J Orthop Trauma. 1999;13:78–84.

    Article  CAS  PubMed  Google Scholar 

  8. Alberts KA, Loohagen G, Einarsdottir H. Open tibial fractures: faster union after unreamed nailing than external fixation. Injury. 1999;30:519–23.

    Article  CAS  PubMed  Google Scholar 

  9. Henley MB, Chapman JRR, Agel J, Harvey EJ, Wharton AM, Swiontkowski MF, et al. Treatment of type II, IIIA, and IIIB open fractures of the tibial shaft: a prospective comparison of unreamed interlocking intramedullary nails and half-pin external fixators. J Orthop Trauma. 1998;12:1–7.

    Article  CAS  PubMed  Google Scholar 

  10. Schandelmaier P, Krettek C, Rudolf J, Kohl A, Katz BE, Tscherne H. Superior results of tibial rodding versus external fixation in grade 3B fractures. Clin Orthop Relat Res. 1997;342:164–72.

    Article  PubMed  Google Scholar 

  11. Tornetta P, Bergman M, Watnik N, Berkowitz G, Steuer J. Treatment of grade-IIIb open tibial fractures. A prospective randomised comparison of external fixation and non-reamed locked nailing. J Bone Jt Surg Br. 1994;76:13–9.

    Google Scholar 

  12. Trlica J, Kočí J, Lochman P, Šmejkal K, Frank M, Holeček T, et al. Reamed versus unreamed nail in the treatment of tibia shaft fractures. Eur J Trauma Emerg Surg. 2013;40:489–93.

    Article  Google Scholar 

  13. Gänsslen A, Gösling T, Hildebrand F, Pape HC, Oestern HJ. Femoral shaft fractures in adults: treatment options and controversies. Acta Chir Orthop Traumatol Cechoslov. 2014;81:108–17.

    Google Scholar 

  14. Nicholas B, Toth L, van Wessem K, Evans J, Enninghorst N, Balogh ZJ. Borderline femur fracture patients: early total care or damage control orthopaedics? ANZ J Surg. 2011;81:148–53.

    Article  PubMed  Google Scholar 

  15. Behrens F, Searls K. External fixation of the tibia. Basic concepts and prospective evaluation. J Bone Jt Surg Br. 1986;68:246–54.

    CAS  Google Scholar 

  16. Burgess AR, Poka A, Brumback RJ, Bosse MJ. Management of open grade III tibial fractures. Orthop Clin N Am. 1987;18:85–93.

    CAS  Google Scholar 

  17. Court-Brown CM, Wheelwright EF, Christie J, McQueen MM. External fixation for type III open tibial fractures. J Bone Jt Surg Br. 1990;72:801–4.

    CAS  Google Scholar 

  18. Giannoudis PV, Papakostidis C, Roberts C. A review of the management of open fractures of the tibia and femur. J Bone Jt Surg Br. 2006;88:281–9.

    Article  CAS  Google Scholar 

  19. Bach AW, Hansen ST. Plates versus external fixation in severe open tibial shaft fractures. A randomized trial. Clin Orthop Relat Res. 1989;241:89–94.

    PubMed  Google Scholar 

  20. Edwards CC, Simmons SC, Browner BD, Weigel MC. Severe open tibial fractures. Results treating 202 injuries with external fixation. Clin Orthop Relat Res. 1988;230:98–115.

    PubMed  Google Scholar 

  21. Holbrook JL, Swiontkowski MF, Sanders R. Treatment of open fractures of the tibial shaft: ender nailing versus external fixation. A randomized, prospective comparison. J Bone Jt Surg Am. 1989;71:1231–8.

    CAS  Google Scholar 

  22. Krettek C, Haas N, Schandelmaier P, Frigg R, Tscherne H. Unreamed tibial nail in tibial shaft fractures with severe soft tissue damage. Initial clinical experiences. Unfallchirurg. 1991;94:579–87.

    CAS  PubMed  Google Scholar 

  23. Stegemann P, Lorio M, Soriano R, Bone L. Management protocol for unreamed interlocking tibial nails for open tibial fractures. J Orthop Trauma. 1995;9:117–20.

    Article  CAS  PubMed  Google Scholar 

  24. Agrawal A, Chauhan VD, Maheshwari RK, Juyal AK. Primary nailing in the open fractures of the Tibia-Is it worth? J Clin Diagn Res. 2013;7:1125–30.

    PubMed Central  PubMed  Google Scholar 

  25. Bhandari M, Guyatt GH, Swiontkowski MF, Schemitsch EH. Treatment of open fractures of the shaft of the tibia. J Bone Jt Surg Am. 2001;83:62–8.

    Article  CAS  Google Scholar 

  26. Tu YK, Lin CH, Su JI, Hsu DT, Chen RJ. Unreamed interlocking nail versus external fixator for open type III tibia fractures. J Trauma. 1995;39:361–7.

    Article  CAS  PubMed  Google Scholar 

  27. Klein MP, Rahn BA, Frigg R, Kessler S, Perren SM. Reaming versus non-reaming in medullary nailing: interference with cortical circulation of the canine tibia. Arch Orthop Trauma Surg. 1990;109:314–6.

    Article  CAS  PubMed  Google Scholar 

  28. Schemitsch EH, Kowalski MJ, Swiontkowski MF, Senft D. Cortical bone blood flow in reamed and unreamed locked intramedullary nailing: a fractured tibia model in sheep. J Orthop Trauma. 1994;8:373–82.

    Article  CAS  PubMed  Google Scholar 

  29. Bone LB, Kassman S, Stegemann P, France J. Prospective study of union rate of open tibial fractures treated with locked, unreamed intramedullary nails. J Orthop Trauma. 1994;8:45–9.

    Article  CAS  PubMed  Google Scholar 

  30. Klein C, Sprecher C, Rahn BA, Green J, Müller CA. Unreamed or RIA reamed nailing: an experimental sheep study using comparative histological assessment of affected bone tissue in an acute fracture model. Injury. 2010;41(Suppl 2):S32–7.

    Article  PubMed  Google Scholar 

  31. Mueller CA, Schlegel V, Hoegel F, Eckhardt C, Schlegel U, Rahn BA, et al. Cortical perfusion and local fat occlusion after intramedullary nailing of the ovine tibia—comparison of different surgical procedures. Injury. 2009;40:760–6.

    Article  CAS  PubMed  Google Scholar 

  32. Finkemeier CG, Schmidt AH, Kyle RF, Templeman DC, Varecka TF. A prospective, randomized study of intramedullary nails inserted with and without reaming for the treatment of open and closed fractures of the tibial shaft. J Orthop Trauma. 2000;14:187–93.

    Article  CAS  PubMed  Google Scholar 

  33. Schemitsch EH, Bhandari M, Guyatt G, Sanders DW, Swiontkowski M, Walter SD, Zdero R, et al. Prognostic factors for predicting outcomes after intramedullary nailing of the tibia. J Bone Jt Surg Am. 2012;19:1786–93.

    Article  Google Scholar 

  34. Keating JF, O’Brien PJ, Blachut PA, Meek RN, Broekhuyse HM. Locking intramedullary nailing with and without reaming for open fractures of the tibial shaft. A prospective, randomized study. J Bone Jt Surg Am. 1997;79:334–41.

    CAS  Google Scholar 

  35. Xue D, Zheng Q, Li H, Qian S, Zhang B, Pan Z. Reamed and unreamed intramedullary nailing for the treatment of open and closed tibial fractures: a subgroup analysis of randomised trials. Int Orthop. 2010;34:1307–13.

    Article  PubMed Central  PubMed  Google Scholar 

  36. Duan X, Zeng Y, Zhang W, Xiang Z. Intramedullary nailing for tibial shaft fractures in adults. Cochrane Database Syst Rev. 2012; doi:10.1002/14651858.

    PubMed  Google Scholar 

  37. Papakostidis C, Kanakaris NK, Pretel J, Faour O, Morell DJ, Giannoudis PV. Prevalence of complications of open tibial shaft fractures stratified as per the Gustilo–Anderson classification. Injury. 2011;42:1408–15.

    Article  PubMed  Google Scholar 

  38. Rajasekaran S, Dheenadhayalan J, Babu JN, Sundararajan SR, Venkatramani H, Sabapathy SR. Immediate primary skin closure in type-III A and B open fractures: results after a minimum of five years. J Bone Jt Surg Br. 2009;91:217–24.

    Article  CAS  Google Scholar 

  39. Patzakis MJ, Bains RS, Lee J, Shepherd L, Singer G, Ressler R, et al. Prospective, randomized, double-blind study comparing single-agent antibiotic therapy, ciprofloxacin, to combination antibiotic therapy in open fracture wounds. J Orthop Trauma. 2000;14:529–33.

    Article  CAS  PubMed  Google Scholar 

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Conflict of interest

Alexander Hofmann, Sven-Oliver Dietz, Philip Pairon, and Pol M. Rommens declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Hofmann, A., Dietz, SO., Pairon, P. et al. The role of intramedullary nailing in treatment of open fractures. Eur J Trauma Emerg Surg 41, 39–47 (2015). https://doi.org/10.1007/s00068-014-0485-5

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  • DOI: https://doi.org/10.1007/s00068-014-0485-5

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