Skip to main content
Log in

Bedeutung der Schnittbildverfahren für das Staging des Rektumkarzinoms

The role of cross-sectional imaging in staging of rectal cancer

  • Leitthema
  • Published:
Der Chirurg Aims and scope Submit manuscript

Zusammenfassung

Die Diversifizierung der Behandlungskonzepte für das Rektumkarzinom wird eine zunehmende Spezialisierung der radiologischen Bildgebung erfordern. Eine Vielzahl von aktuellsten Studien belegt, dass die MRT in der Lage ist, die für Therapieentscheidung und Prognose relevanten Parameter zu bestimmen. Die CT besitzt im Hinblick auf das lokale Staging keinen Stellenwert, wird aber vielerorts noch das 1. Verfahren zur Abklärung von Fernmetastasen bleiben. Mit steigender Akzeptanz können hier umfassendere, MR-basierte Stagingkonzepte zu einer Vereinfachung und Kostenreduktion des bisherigen Patientenmanagements beitragen. Die FDG-PET/CT hat ihren Stellenwert in der Response-Evaluation und Rezidivdiagnostik, wird aber gegenwärtig nicht für den Einsatz in der klinischen Routine empfohlen.

Abstract

The ongoing diversification of treatment strategies for rectal cancer justifies the demand for highly specialized radiological imaging. Currently, numerous studies have underlined the ability of magnetic resonance imaging (MRI) to determine those parameters that are critical for therapeutic decision-making and prognosis in rectal cancer. Computed tomography (CT) does not meet the criteria of a first line diagnostic procedure with regard to local staging but will remain the workhorse in the search for distant metastases. The increasing acceptance of extended MRI-based concepts will, however, improve cost-effectiveness and simplify patient management. Response evaluation and detection of recurrent disease are the major indications for positron emission tomography (PET)/CT, which is currently not routinely recommended.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6

Literatur

  1. Barbaro B, Vitale R, Valentini V et al (2011) Diffusion-weighted magnetic resonance imaging in monitoring rectal cancer response to neoadjuvant chemoradiotherapy. Int J Radiat Oncol Biol Phys [Epub ahead of print]

  2. Beets-Tan RG Beets Gl (2011) Local staging of rectal cancer: a review of imaging. J Magn Reson Imaging 33:1012–1019

    Article  PubMed  Google Scholar 

  3. Braendengen M, Hansson K, Radu C et al (2011) Delineation of gross tumor volume (GTV) for radiation treatment planning of locally advanced rectal cancer using information from MRI or FDG-PET/CT: a prospective study. Int J Radiat Oncol Biol Phys 81:e439–445

    Article  PubMed  Google Scholar 

  4. Brush J, Boyd K, Chappell F et al (2011) The value of FDG positron emission tomography/computerised tomography (PET/CT) in pre-operative staging of colorectal cancer: a systematic review and economic evaluation. Health Technol Assess 15:1–192, iii-iv

    PubMed  CAS  Google Scholar 

  5. Curvo-Semedo L, Lambregts DM, Maas M et al (2012) Diffusion-weighted MRI in rectal cancer: Apparent diffusion coefficient as a potential noninvasive marker of tumor aggressiveness. J Magn Reson Imaging [Epub ahead of print]

  6. Curvo-Semedo L, Lambregts DM, Maas M et al (2011) Rectal cancer: assessment of complete response to preoperative combined radiation therapy with chemotherapy–conventional MR volumetry versus diffusion-weighted MR imaging. Radiology 260:734–743

    Article  PubMed  Google Scholar 

  7. Gollub MJ, Gultekin DH, Akin O et al (2011) Dynamic contrast enhanced-MRI for the detection of pathological complete response to neoadjuvant chemotherapy for locally advanced rectal cancer. Eur Radiol [Epub ahead of print]

  8. Gu J, Khong PL, Wang S et al (2011) Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: correlation with FDG-PET/CT. Mol Imaging Biol 13:1020–1028

    Article  PubMed  Google Scholar 

  9. Habr-Gama A, Perez RO, Sao Juliao GP et al (2011) Nonoperative approaches to rectal cancer: a critical evaluation. Semin Radiat Oncol 21:234–239

    Article  PubMed  Google Scholar 

  10. Hawkes EA, Cunningham D, Tait D et al (2011) Neoadjuvant chemotherapy alone for early-stage rectal cancer: an evolving paradigm? Semin Radiat Oncol 21:196–202

    Article  PubMed  Google Scholar 

  11. Huh JW, Min JJ, Lee JH et al (2011) The predictive role of sequential FDG-PET/CT in response of locally advanced rectal cancer to neoadjuvant chemoradiation. Am J Clin Oncol [Epub ahead of print]

  12. Huppertz A, Schmidt M, Wagner M et al (2010) Whole-body MR imaging versus sequential multimodal diagnostic algorithm for staging patients with rectal cancer: cost analysis. Rofo 182:793–802

    Article  PubMed  CAS  Google Scholar 

  13. Kim CK, Kim SH, Choi D et al (2007) Comparison between 3-T magnetic resonance imaging and multi-detector row computed tomography for the preoperative evaluation of rectal cancer. J Comput Assist Tomogr 31:853–859

    Article  PubMed  Google Scholar 

  14. Kuremsky JG, Tepper JE, McLeod HL (2009) Biomarkers for response to neoadjuvant chemoradiation for rectal cancer. Int J Radiat Oncol Biol Phys 74:673–688

    Article  PubMed  CAS  Google Scholar 

  15. Lambregts DM, Maas M, Bakers FC et al (2011) Long-term follow-up features on rectal MRI during a wait-and-see approach after a clinical complete response in patients with rectal cancer treated with chemoradiotherapy. Dis Colon Rectum 54:1521–1528

    Article  PubMed  Google Scholar 

  16. Lambregts DM, Maas M, Cappendijk VC et al (2011) Whole-body diffusion-weighted magnetic resonance imaging: current evidence in oncology and potential role in colorectal cancer staging. Eur J Cancer 47:2107–2116

    Article  PubMed  Google Scholar 

  17. Lambregts DM, Vandecaveye V, Barbaro B et al (2011) Diffusion-weighted MRI for selection of complete responders after chemoradiation for locally advanced rectal cancer: a multicenter study. Ann Surg Oncol 18:2224–2231

    Article  PubMed  Google Scholar 

  18. Maas M, Beets-Tan RG, Lambregts DM et al (2011) Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol 29:4633–4640

    Article  PubMed  Google Scholar 

  19. Maizlin ZV, Brown JA, So G et al (2011) Can CT replace MRI in preoperative assessment of the circumferential resection margin in rectal cancer? Dis Colon Rectum 53:308–314

    Article  Google Scholar 

  20. Mathis KL, Larson DW, Dozois EJ et al (2012) Outcomes following surgery without radiotherapy for rectal cancer. Br J Surg 99:137–143

    Article  PubMed  CAS  Google Scholar 

  21. Oberholzer K, Menig M, Kreft A et al (2012) Rectal cancer: mucinous carcinoma on magnetic resonance imaging indicates poor response to neoadjuvant chemoradiation. Int J Radiat Oncol Biol Phys 82:842–848

    Article  PubMed  Google Scholar 

  22. Patel UB, Taylor F, Blomqvist L et al (2011) Magnetic resonance imaging-detected tumor response for locally advanced rectal cancer predicts survival outcomes: MERCURY experience. J Clin Oncol 29:3753–3760

    Article  PubMed  Google Scholar 

  23. Pedersen BG, Moran B, Brown G et al (2011) Reproducibility of depth of extramural tumor spread and distance to circumferential resection margin at rectal MRI: enhancement of clinical guidelines for neoadjuvant therapy. AJR Am J Roentgenol 197:1360–1366

    Article  PubMed  Google Scholar 

  24. Rodel C, Arnold D, Becker H et al (2010) Induction chemotherapy before chemoradiotherapy and surgery for locally advanced rectal cancer: is it time for a randomized phase III trial? Strahlenther Onkol 186:658–664

    Article  PubMed  Google Scholar 

  25. Schaefer AO, Langer M, Baumann T (2010) Continuously moving table MRI in oncology. Rofo 182:954–964

    Article  PubMed  Google Scholar 

  26. Secco GB, Fardelli R, Campora E et al (1994) Primary mucinous adenocarcinomas and signet-ring cell carcinomas of colon and rectum. Oncology 51:30–34

    Article  PubMed  CAS  Google Scholar 

  27. Shihab OC, Heald RJ, Rullier E et al (2009) Defining the surgical planes on MRI improves surgery for cancer of the low rectum. Lancet Oncol 10:1207–1211

    Article  PubMed  Google Scholar 

  28. Shihab OC, How P, West N et al (2011) Can a novel MRI staging system for low rectal cancer aid surgical planning? Dis Colon Rectum 54:1260–1264

    Article  PubMed  Google Scholar 

  29. Shihab OC, Taylor F, Salerno G et al (2011) MRI predictive factors for long-term outcomes of low rectal tumours. Ann Surg Oncol 18:3278–3284

    Article  PubMed  Google Scholar 

  30. Simunovic M, Jacob S, Coates AJ et al (2011) Outcomes following a limited approach to radiotherapy in rectal cancer. Br J Surg 98:1483–1488

    Article  PubMed  CAS  Google Scholar 

  31. Smith NJ, Barbachano Y, Norman AR et al (2008) Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer. Br J Surg 95:229–236

    Article  PubMed  CAS  Google Scholar 

  32. Smith NJ, Shihab O, Arnaout A et al (2008) MRI for detection of extramural vascular invasion in rectal cancer. AJR Am J Roentgenol 191:1517–1522

    Article  PubMed  Google Scholar 

  33. Taylor FG, Quirke P, Heald RJ et al (2011) Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone: a prospective, multicenter, European study. Ann Surg 253:711–719

    Article  PubMed  Google Scholar 

  34. Van Den Bogaard J, Janssen MH, Janssens G et al (2011) Residual metabolic tumor activity after chemo-radiotherapy is mainly located in initially high FDG uptake areas in rectal cancer. Radiother Oncol 99:137–141

    Article  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A.O. Schäfer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schäfer, A., Langer, M. & Baumann, T. Bedeutung der Schnittbildverfahren für das Staging des Rektumkarzinoms. Chirurg 83, 439–447 (2012). https://doi.org/10.1007/s00104-011-2204-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00104-011-2204-7

Schlüsselwörter

Keywords

Navigation