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The interaction between ischemia–reperfusion and immune responses in the kidney

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Abstract

Kidney ischemia–reperfusion injury (IRI) engages both the innate and adaptive immune responses. Cellular mediators of immunity, such as dendritic cells, neutrophils, macrophages, natural killer T, T, and B cells, contribute to the pathogenesis of renal injury after IRI. Postischemic kidneys express increased levels of adhesion molecules on endothelial cells and toll-like receptors on tubular epithelial cells. Soluble components of the immune system, such as complement activation proteins and cytokines, also participate in injury/repair of postischemic kidneys. Experimental studies on the immune response in kidney IRI have resulted in better understanding of the mechanisms underlying IRI and led to the discovery of novel therapeutic and diagnostic targets.

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Acknowledgments

The authors thank Dr. Maria Teresa Gandolfo for the helpful suggestions with the manuscript. HR is supported by the US National Institutes of Health, US National Kidney Foundation, and Talecris Biotech., Inc. grants. BAW is supported by AHA, ROTRF, and Talecris Biotech., Inc. grants. HRJ is supported by the Korea Research Foundation.

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Authors and Affiliations

  1. Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Ross Building, Room 965, 720 Rutland Avenue, Baltimore, MD, 21205, USA

    Hye Ryoun Jang, Gang Jee Ko & Hamid Rabb

  2. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Barbara A. Wasowska

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  1. Hye Ryoun Jang
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  2. Gang Jee Ko
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  3. Barbara A. Wasowska
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  4. Hamid Rabb
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Correspondence to Hamid Rabb.

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Jang, H.R., Ko, G.J., Wasowska, B.A. et al. The interaction between ischemia–reperfusion and immune responses in the kidney. J Mol Med 87, 859–864 (2009). https://doi.org/10.1007/s00109-009-0491-y

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  • DOI: https://doi.org/10.1007/s00109-009-0491-y

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