Abstract
Dietary changes are an attractive means of protecting against environmental chemical exposure. Exposure to benzo[a]pyrene (B[a]P) is a risk factor for cardiovascular disease events. It has recently been shown that B[a]P can increase intercellular adhesion molecule-1 (ICAM-1) in endothelial cells, a possible means of promoting cardiovascular disease. This study investigated the ability of flavonoids to protect against B[a]P-induced ICAM-1. It was shown that only flavonoids that contain a 4′ B-ring hydroxyl substitution and a 2–3 C-ring double bond were protective. These data suggest that selected bioactive compounds can decrease proinflammatory properties of environmental chemicals such as B[a]P.
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Acknowledgments
We would like to thank Dr. Thomas Curry and the UK Labor and Delivery staff for help obtaining human umbilical cords. We would like to thank the UK Flow Cytometry Facility for their help in analyzing the flow data. This research was supported by grants from NIEHS/NIH (P42ES07380), AHA Pre-doctoral Fellowship (0613216B), and the University of Kentucky Agricultural Experiment Station.
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Owens, E.O., Toborek, M. & Hennig, B. Flavonoids Protect Against Intercellular Adhesion Molecule-1 Induction by Benzo[a]pyrene. Bull Environ Contam Toxicol 83, 4–7 (2009). https://doi.org/10.1007/s00128-009-9664-1
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DOI: https://doi.org/10.1007/s00128-009-9664-1