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Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment?

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An Erratum to this article was published on 08 August 2014

Abstract

The conclusion of a series of recent reports highlights the significant neurotoxic effects that rare earth elements, such as lanthanum (La), can have during neurodevelopment. These findings are, herein, combined and presented using a simplified schematic overview that provides a putative solution to the riddle of La-induced cognitive impairment. Our commentary also highlights potential targets for further investigations into the mechanisms which underpin La-induced neurotoxicity, with a focus on the crucial role of the hippocampus. Within this context, a central role for the cyclic-adenosine monophosphate signalling pathway is proposed.

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Conflict of interest

All authors (AZ, AMB, SDB, ST and GSB) declare that there are no conflicts of interest.

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Authors and Affiliations

  1. Gardiner Laboratory (535), Wolfson Link Building, College of Medical, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Box 318, 111 West George Str., Glasgow, G2-1QX, Scotland, UK

    Apostolos Zarros, Ashleigh-Maria Byrne & George S. Baillie

  2. Laboratory of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Apostolos Zarros & Stylianos Tsakiris

  3. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, UK

    Stephanie D. Boomkamp

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  1. Apostolos Zarros
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  2. Ashleigh-Maria Byrne
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  3. Stephanie D. Boomkamp
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  4. Stylianos Tsakiris
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  5. George S. Baillie
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Correspondence to Apostolos Zarros.

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Zarros, A., Byrne, AM., Boomkamp, S.D. et al. Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment?. Arch Toxicol 87, 2031–2035 (2013). https://doi.org/10.1007/s00204-013-1112-7

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  • DOI: https://doi.org/10.1007/s00204-013-1112-7

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